In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease
In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease
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DOI：
10.1016/j.parkreldis.2012.07.002
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发表时间：
2013-01-01
影响因子：
4.1
通讯作者：
Perani, D.
中科院分区：
文献类型：
--
作者：
Iannaccone, S.;Cerami, C.;Perani, D.
背景资料：反应性小胶质细胞增生是神经炎症的标志，可能导致神经元变性，如在几种神经退行性疾病中所示。我们在体内评估了早期路易体痴呆中小胶质细胞的激活，并与早期帕金森病进行了比较，以评估可能的差异病理模式。方法：我们使用简化的参考组织模型，用正电子发射断层扫描测量了[C-11]-PK 11195结合电位，作为小胶质细胞活化的标志物，以及脑脊液蛋白羰基化水平，作为氧化应激的标志。研究对象包括6名路易体痴呆患者和6名帕金森病患者，以及11名健康对照者。临床诊断在www.example.com随访中得到证实4-ye.ar。在路易体痴呆和帕金森病中，我们发现黑质和壳核中[C-11]-PK 11195结合潜力显著增加（p < 0.001）。路易体痴呆患者在几个联合皮层中有广泛的额外小胶质细胞激活。这一点在单个主题层面也很明显。脑脊液蛋白羰基化显着增加，在两个patients'group.Conclusions：[C-11]-PK 11195正电子发射断层扫描成像显示神经炎症痴呆路易体和帕金森病，镜像，即使在一个单一的主题水平，共同和不同的地形分布的神经病理变化，但在疾病过程的最早阶段。关注帕金森综合征和帕金森病的特征事件可能是进一步推进对发病机制的理解并将这些机制作为确定神经保护靶点的关键。(c)2012由Elsevier Ltd.出版
Background: Reactive microgliosis, hallmark of neuroinflammation, may contribute to neuronal degeneration, as shown in several neurodegenerative diseases. We in vivo evaluated microglia activation in early dementia with Lewy bodies, still not reported, and compared with early Parkinson's disease, to assess possible differential pathological patterns.Methods: We measured the [C-11]-PK11195 binding potentials with Positron Emission Tomography, using a simplified reference tissue model, as marker of microglia activation, and cerebral spinal fluid protein carbonylation levels, as marker of oxidative stress. Six dementia with Lewy bodies and 6 Parkinson's disease patients within a year from the onset, and eleven healthy controls were included. Clinical diagnosis was confirmed at a 4-ye.ar follow-up.Results: In dementia with Lewy bodies as well as in Parkinson's disease, we found significant (p < 0.001) [C-11]-PK11195 binding potential increases in the substantia nigra and putamen. Patients with Lewy bodies dementia had extensive additional microglia activation in several associative cortices. This was evident also at a single subject level. Significant increase of Cerebral Spinal Fluid protein carbonylation was shown in both patients' groups.Conclusions: [C-11]-PK11195 Positron Emission Tomography imaging revealed neuroinflammation in dementia with Lewy bodies and Parkinson's disease, mirroring, even at a single subject level, the common and the different topographical distribution of neuropathological changes, yet in the earliest stages of the disease process. Focusing on those events that characterize parkinsonisms and Parkinson's disease may be the key to further advancing the understanding of pathogenesis and to taking these mechanisms forward as a means of defining targets for neuroprotection. (c) 2012 Published by Elsevier Ltd.