Multispectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast.
Multispectral near-infrared tomography: a case study in compensating for water and lipid content in hemoglobin imaging of the breast.
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DOI：
10.1117/1.1428290
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发表时间：
2002
影响因子：
3.5
通讯作者：
T. O. McBride;B. Pogue;S. Poplack;Sandra K. Soho;W. Wells;Shudong Jiang;U. Osterberg;K. Paulsen
中科院分区：
文献类型：
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作者：
T. O. McBride;B. Pogue;S. Poplack;Sandra K. Soho;W. Wells;Shudong Jiang;U. Osterberg;K. Paulsen
通过对患有侵袭性癌症的女性的乳房进行多光谱近红外断层扫描测量，可以显示血红蛋白浓度和氧饱和度的图像。使用基于频域扩散方程的有限元重建算法从测量数据中恢复吸收系数和减少散射系数的图像。提出了三种恢复血红蛋白浓度和氧饱和度图像的方法，以不同的方式补偿水和脂质的吸收：（1）使用假定的水和脂质的大量含量，（2）对四个生色团进行成像，以及（3）应用散射功率数据来推断水和脂质图像。在所有三种情况下，在癌症位置观察到血红蛋白浓度大幅增加 (3:1)，而在这些水和脂质补偿方法之间的血红蛋白图像中观察到最大 15% 的差异。
Images of hemoglobin concentration and oxygen saturation are presented from multispectral near-infrared tomographic measurements in the breast of a woman with an invasive cancer. Images of the absorption coefficient and reduced scattering coefficient are recovered from the measured data using a finite element reconstruction algorithm based on the frequency-domain diffusion equation. Three methods of recovering the hemoglobin concentration and oxygen saturation images are presented which compensate for water and lipid absorption in different ways: (1) an assumed bulk content of water and lipids is used, (2) four chromophores are imaged, and (3) scattering power data are applied to deduce water and lipid images. In all three cases, a large increase in the hemoglobin concentration (3:1) is observed at the location of the cancer while a maximum of 15% difference is observed in the hemoglobin images between each of these methods for water and lipid compensation.