Suppression of human papillomavirus gene expression in vitro and in vivo by herpes simplex virus type 2 infection.
Suppression of human papillomavirus gene expression in vitro and in vivo by herpes simplex virus type 2 infection.
复制标题
2 型单纯疱疹病毒感染在体外和体内抑制人乳头瘤病毒基因表达。
DOI：
10.1016/s0042-6822(03)00440-9
复制
发表时间：
2003
期刊：
影响因子：
3.7
通讯作者：
Howett,MK
中科院分区：
文献类型：
--
作者：
Fang,L;Ward,MG;Welsh,PA;Budgeon,LR;Neely,EB;Howett,MK
Recent epidemiological studies have found that women infected with both herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) type 16 or HPV-18 are at greater risk of developing cervical carcinoma compared to women infected with only one virus. However, it remains unclear if HSV-2 is a cofactor for cervical cancer or if HPV and HSV-2 interact in any way. We have studied the effect of HSV-2 infection on HPV-11 gene expression in an in vitro double-infection assay. HPV transcripts were down-regulated in response to HSV-2 infection. Two HSV-2 vhs mutants failed to reduce HPV-16 E1^E4 transcripts. We also studied the effect of HSV-2 infection on preexisting experimental papillomas in a vaginal epithelial xenograft model. Doubly infected grafts demonstrated papillomatous transformation and the classical cytopathic effect from HSV-2 infection. HPV and HSV DNA signals were mutually exclusive. These studies may have therapeutic applications for HPV infections and related neoplasms.
