A genetic variant of the atrial natriuretic peptide gene is associated with left ventricular hypertrophy in a non-diabetic population - the Malmo preventive project study
A genetic variant of the atrial natriuretic peptide gene is associated with left ventricular hypertrophy in a non-diabetic population - the Malmo preventive project study
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DOI：
10.1186/1471-2350-14-64
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发表时间：
2013-06-24
影响因子：
--
通讯作者：
Magnusson, Martin
中科院分区：
文献类型：
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作者：
Jujic, Amra;Leosdottir, Margret;Magnusson, Martin
背景：流行病学研究表明，血压具有相当大的遗传性，从而表明遗传因素的作用。先前的研究表明，NPPA基因座基因中的单核苷酸多态性rs 5068与较高水平的循环心钠素以及较低的个体内血压相关，但迄今为止，rs 5068与心脏器官损伤（即左心室肥大）之间没有相关性。我们试图探讨是否rs 5068与左心室肥厚的超声心动图检查在non-diabetic population.Methods：968非糖尿病个体从马尔莫预防项目（平均年龄67岁，31%的妇女）进行了基因分型和超声心动图检查。Logistic回归用于调整协变量。结果：在调整性别和年龄后，rs 5068的次要等位基因与左心室肥厚的患病率降低相关（p = 0.021）。在多变量logistic分析，包括年龄，性别，收缩压，抗高血压和/或心脏保护治疗，体重指数和空腹血糖，关联rs 5068与左心室肥厚，如预期的，衰减（p = 0.061）。结论：在非糖尿病人群中，次要等位基因rs 5068与左心室质量较低。这些发现表明rs 5068或连锁不平衡的遗传变异可能影响左心室肥大的易感性，并支持利钠肽可能的保护作用。
Background: Epidemiological studies have shown considerable heritability of blood pressure, thus suggesting a role for genetic factors. Previous studies have shown an association of a single nucleotide polymorphism rs5068 in the NPPA locus gene with higher levels of circulating atrial natriuretic peptide as well as with lower intra individual blood pressure, but up to date, no association between rs5068 and cardiac organ damage, i.e. left ventricular hypertrophy, has been accounted for in humans. We sought to explore if rs5068 is associated with left ventricular hypertrophy as measured by echocardiographic examination in a non-diabetic population.Methods: 968 non-diabetic individuals from the Malmo Preventive Project (mean age 67 years; 31% women) were genotyped and examined with echocardiography. Logistic regression was used to adjust for covariates.Results: The minor allele of rs5068 was associated with decreased prevalence of left ventricular hypertrophy (p = 0.021) after adjustment for sex and age. In the multivariate logistic analysis including; age, sex, systolic blood pressure, antihypertensive and/or cardioprotective treatment, body mass index and fasting plasma glucose, the association of rs5068 with left ventricular hypertrophy was, as expected, attenuated (p = 0.061).Conclusion: In a non-diabetic population, the minor allele of rs5068 was associated with lower left ventricular mass. These findings suggest that rs5068, or genetic variants in linkage disequilibrium, might affect susceptibility to left ventricular hypertrophy and support the possible protective role of natriuretic peptides.