Evidence of the antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behavior
Evidence of the antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behavior
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DOI：
10.1016/j.yebeh.2004.01.005
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发表时间：
2004-06-01
影响因子：
2.6
通讯作者：
Vohora, D
中科院分区：
文献类型：
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作者：
Ali, A;Jalees, F;Vohora, D
大脑中的钠氢交换器 (NHE) 在调节神经元 pH 值方面发挥着关键作用，从而调节生物电和癫痫活动。在这项研究中，我们研究了阿米洛利（一种 NHE 抑制剂）对增加电流电击 (ICES) 和戊四唑 (PTZ) 诱导的小鼠癫痫发作的抗惊厥作用。此外，还评估了阿米洛利对情绪、记忆力、握力和转棒表现的影响。采用强迫游泳测试（FST）和自发交替行为（SAB）模型分别评估对情绪和记忆的影响。阿米洛利在两种啮齿动物癫痫模型中均导致癫痫阈值呈剂量依赖性增加。据观察，阿米洛利可减少小鼠 FST 中的行为抑郁。此外，它还提高了 SAB 模型的记忆力。阿米洛利不影响握力和转棒性能，表明它没有行为障碍。结果表明阿米洛利具有潜在的抗癫痫活性以及额外的神经学优势。 (C) 2004 Elsevier Inc. 保留所有权利。
Sodium-hydrogen exchangers (NHEs) in the brain play a key role in regulating neuronal pH and, hence, modulate bioelectric and seizure activity. In this study, we investigated the anticonvulsant effect of amiloride (a NHE inhibitor) on increasing current electroshock (ICES) and pentylenetetrazole (PTZ)-induced seizures in mice. Further, the effect of amiloride on mood, memory, grip strength, and rotarod performance was also evaluated. The forced swimming test (FST) and spontaneous alternation behavior (SAB) models were employed to assess the effects on mood and memory, respectively. Amiloride produced a dose-dependent increase in seizure threshold in both rodent models of epilepsy. It was observed that amiloride reduced behavioral depression in the FST in mice. In addition, it resulted in memory improvement in the SAB model. Amiloride did not affect grip strength and rotarod performance, suggesting it is devoid of behavioral impairment. The results indicate the potential antiseizure activity of amiloride along with additional neurological advantages. (C) 2004 Elsevier Inc. All rights reserved.