AMPHIPATHIC ANALYSIS AND POSSIBLE FORMATION OF THE ION CHANNEL IN AN ACETYLCHOLINE-RECEPTOR
AMPHIPATHIC ANALYSIS AND POSSIBLE FORMATION OF THE ION CHANNEL IN AN ACETYLCHOLINE-RECEPTOR
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DOI：
10.1073/pnas.81.1.155
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
STROUD, RM
中科院分区：
文献类型：
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作者：
FINERMOORE, J;STROUD, RM
乙酰胆碱受体亚基序列的疏水性的傅立叶分析揭示了两亲性二级结构的区域。基于这种分析和经验预测方法的共识二级结构的预测导致关于离子通道如何形成和可能起作用的可检验的假设。乙酰胆碱受体的三维结构的知识与所提出的模型的功能是一致的，并提供了一些限制。
Fourier analysis of the hydrophobicities of the acetylcholine receptor subunit sequences reveals regions of amphipathic secondary structure. Prediction of a consensus secondary structure based on this analysis and on an empirical prediction method leads to a testable hypothesis about how the ion channel is formed and might function. Knowledge of the 3-dimensional structure of acetylcholine receptors is consistent with features of the model proposed and provides some constraints.