Application of end-systolic pressure-volume and pressure-wall thickness relations in conscious dogs.
Application of end-systolic pressure-volume and pressure-wall thickness relations in conscious dogs.
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收缩末压-容积和压力-壁厚度关系在清醒狗中的应用。
DOI：
10.1016/s0735-1097(87)80092-x
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发表时间：
1987
影响因子：
24
通讯作者：
RossJr,J
中科院分区：
文献类型：
--
作者：
Lee,JD;Tajimi,T;Widmann,TF;RossJr,J
在清醒的狗身上比较收缩末期测量的心功能与标准收缩指数的有用性。本文分析了用超声晶体测量的犬的左心室收缩末期压力与容量以及压力与室壁厚度之间的关系。渐进的血管紧张素注射被用来产生计算机平均的压力-体积和压力-壁厚曲线。在每项研究中，这两种关系都是线性的，且重复性很高。使用低剂量和大剂量多巴酚丁胺后，收缩末期压力-容量关系显著移位，斜率增加，截距变化不一致。此关系式在检测不同后负荷时较射血分数更有价值，但在所有前负荷和后负荷范围内均不优于最大左心室dp/dt。收缩末期压力-容量关系对检测心得安引起的肌力状态轻度降低不敏感，最大dp/dt对检测这种轻微的急性收缩功能降低更好。收缩期末压力-室壁厚度关系显示多巴酚丁胺引起的位移，尽管斜率和截距变化不显著；这些关系没有检测到心得安引起的收缩能力轻度下降。结论：收缩期末压力-体积关系和简化的收缩期末压力和室壁厚度测量方法为确定清醒动物左室收缩能力的急性增加提供了灵敏、非负荷和可重复性的方法。最大dp/dt对于确定这些收缩能力的增加同样有效，而对于检测轻微的急性收缩能力下降更敏感。
The usefulness of end-systolic measures of ventricular function was compared with that of standard contractility indexes in conscious dogs. End-systolic relations between left ventricular pressure and volume and between pressure and wall thickness were analyzed in dogs previously instrumented with ultrasonic crystals. Progressive angiotensin infusions were used to generate computer-averaged pressure-volume and pressure-wall thickness loops. Both relations were linear in every study and highly reproducible.With low and high dose dobutamine, the end-systolic pressure-volume relations were significantly displaced, with increased slope and inconsistent changes in intercept. This relation was more useful than the ejection fraction for detecting contractility increases at different afterloads, but it showed no advantage over maximal left ventricular dP/dt at all ranges of preload and after-load. The end-systolic pressure-volume relations were insensitive for detecting mild decreases in inotropic state produced by propranolol, and maximal dP/dt was superior for detecting such mild acutely reduced contractility. The end-systolic pressure-wall thickness relations showed displacement with dobutamine, although slope and intercept changes were not significant; these relations did not detect mild decreases in contractility produced by propranolol.It is concluded that the end-systolic pressure-volume relation and a simplified end-systolic measure using pressure and wall thickness provide sensitive, load-independent and reproducible approaches for defining acute increases in left ventricular contractility in conscious animals. Maximal dP/dt was equally effective for defining these increases in contractility and more sensitive for detecting slight acute decreases in contractility.
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血管紧张素增加心室射血阻力对人体左心室功能的研究
影响因子：
37.8
作者：
J. Ross;E. Braunwald
通讯作者：
E. Braunwald
肥大的左心室功能亢进且正性肌力状态正常。
影响因子：
--
作者：
S. Sasayama;D. Franklin;J. Ross
通讯作者：
J. Ross
影响因子：
37.8
作者：
BOROW, KM;NEUMANN, A;WYNNE, J
通讯作者：
WYNNE, J
在完整猪心脏中使用容量加载技术的区域收缩末期压力-长度关系
影响因子：
20.1
作者：
W. Miller;A. Liedtke;S. Nellis;G. Copenhaver;L. Whitesell
通讯作者：
L. Whitesell
正常有意识的狗的收缩压与直径的关系。
影响因子：
10.8
作者：
Felix Mahler;J. Covell;John Ross
通讯作者：
John Ross