Prospective Study on Waist Circumference and Risk of All-Cause and Cardiovascular Mortality - Pooled Analysis of Japanese Community-Based Studies
Prospective Study on Waist Circumference and Risk of All-Cause and Cardiovascular Mortality - Pooled Analysis of Japanese Community-Based Studies
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DOI：
10.1253/circj.cj-11-1259
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发表时间：
2012-12-01
影响因子：
3.3
通讯作者：
Miyamoto, Yoshihiro
中科院分区：
文献类型：
--
作者：
Saito, Isao;Kokubo, Yoshihiro;Miyamoto, Yoshihiro
背景：本研究的目的是在相对较瘦的日本受试者中阐明腰围与全因和心血管疾病(CVD)死亡风险之间的关系。方法和结果：对3554名没有心血管疾病病史的男性和4472名女性进行了检查，并在基线水平上测量了他们的腰围。受试者年龄为10岁，来自1988-1996年间的3项前瞻性队列研究。在调整了研究队列、年龄、吸烟、饮酒、高血压、血脂异常和糖尿病后，使用COX比例风险模型和惩罚样条法分析了14.7年随访期间全因死亡率和心血管疾病死亡率的风险比。与腰围最低的五分之一相比，男性腰围最高的五分之一与全因死亡风险的线性降低有关(多变量调整后的危险比，0.73；95%可信区间：0.6-0.89；趋势P=0.001)。65岁腰围较高的男性心血管疾病死亡风险增加。这段关系是U型的。在女性中，腰围与全因或心血管疾病死亡风险无关。结论：在男性中，腰围与全因死亡风险的增加呈负相关，而在女性中则不是。腰围较大的中年男性可能会增加心血管疾病死亡的风险。(保监会J 2012；76：2867-2874)
Background: The aim of the present study was to clarify the association between waist circumference and all-cause and cardiovascular disease (CVD) mortality risk in relatively lean Japanese subjects.Methods and Results: A total of 3,554 men and 4,472 women who had no history of CVD were examined and their waist circumference measured at baseline. The subjects were aged >= 10 years and were obtained from 3 prospective cohort studies during 1988-1996. Hazard ratios for all-cause and CVD mortality were analyzed over a follow-up period Of 14.7 years using a Cox proportional hazards model and penalized spline method, after adjustment for study cohort, age, smoking, alcohol drinking, hypertension, dyslipidemia, and diabetes. Compared with the lowest quintile, the highest quintile of waist circumference in men was associated with a linear reduction in all-cause mortality risk (multivariate-adjusted hazard ratio, 0.73; 95% confidence interval: 0.60-0.89; P for trend=0.001). CVD mortality risk was increased in men aged 65 years with a higher waist circumference. This relationship was U-shaped. Waist circumference was not associated with all-cause or CVD mortality risk in women.Conclusions: Waist circumference was associated inversely with increased risk of all-cause death in men, but not in women. Middle-aged men with a greater waist circumference potentially have an increased risk of CVD mortality. (Circ J 2012; 76: 2867-2874)