Caste-specific RNA editomes in the leaf-cutting ant Acromyrmex echinatior.

Caste-specific RNA editomes in the leaf-cutting ant Acromyrmex echinatior.
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切叶蚁 Acromyrmex echinatior 中种姓特异性 RNA 编辑组

DOI:
10.1038/ncomms5943
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发表时间:
2014-09-30
影响因子:
16.6
通讯作者:
Zhang, Guojie
Zhang, Guojie
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Li, Qiye;Wang, Zongji;Lian, Jinmin;Schiott, Morten;Jin, Lijun;Zhang, Pei;Zhang, Yanyan;Nygaard, Sanne;Peng, Zhiyu;Zhou, Yang;Deng, Yuan;Zhang, Wenwei;Boomsma, Jacobus J.;Zhang, Guojie

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真社会性昆虫已经进化出从同一基因组产生具有不同形态、生殖和行为表型的成虫的能力。最近的研究表明,RNA编辑可能会在转录后水平上增强基因产物的多样性,特别是诱导神经系统的功能变化。使用切叶蚁Acromyrmex echinatior的头部样本,我们比较RNA编辑组跨真社会种姓,确定CA。11,000个RNA编辑位点在gynes,大型工人和小型工人。这些编辑位点映射到800个功能丰富的基因,用于神经传递、昼夜节律、温度反应、RNA剪接和羧酸生物合成。大多数A.棘突编辑位点是物种特异性的,但8-23%在蚂蚁亚科中是保守的,并且可能对蚂蚁的真社会性进化很重要。不同等级的同一位点的编辑水平不同,这表明RNA编辑可能是塑造蚂蚁等级行为的一般机制。
Eusocial insects have evolved the capacity to generate adults with distinct morphological, reproductive and behavioural phenotypes from the same genome. Recent studies suggest that RNA editing might enhance the diversity of gene products at the post-transcriptional level, particularly to induce functional changes in the nervous system. Using head samples from the leaf-cutting ant Acromyrmex echinatior, we compare RNA editomes across eusocial castes, identifying ca. 11,000 RNA editing sites in gynes, large workers and small workers. Those editing sites map to 800 genes functionally enriched for neurotransmission, circadian rhythm, temperature response, RNA splicing and carboxylic acid biosynthesis. Most A. echinatior editing sites are species specific, but 8-23% are conserved across ant subfamilies and likely to have been important for the evolution of eusociality in ants. The level of editing varies for the same site between castes, suggesting that RNA editing might be a general mechanism that shapes caste behaviour in ants.
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