Social preference and maternal defeat-induced social avoidance in virgin female rats: Sex differences in involvement of brain oxytocin and vasopressin
Social preference and maternal defeat-induced social avoidance in virgin female rats: Sex differences in involvement of brain oxytocin and vasopressin
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DOI：
10.1016/j.jneumeth.2014.03.013
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发表时间：
2014-08-30
影响因子：
3
通讯作者：
Neumann, Inga D.
中科院分区：
文献类型：
--
作者：
Lukas, Michael;Neumann, Inga D.
工作背景：关于啮齿类动物非生殖社会性的研究主要限于评估催产素（OXT）和精氨酸加压素（AVP）在雄性大鼠和小鼠中的作用。比较研究自然的社会偏好和社会回避在females.New方法：在这里，我们采用了一种行为范式监测社会偏好的雌性大鼠组成的两个连续暴露于非社会或社会的刺激。此外，诱导刺激特定的社会回避，雌性大鼠暴露于一个单一的10分钟的母亲失败的哺乳dam.Results：对同性同种雌性大鼠的社会偏好被证明是独立的发情周期，甚至比雄性大鼠更明显。脑室内（冰）应用OXT，AVP，或其选择性受体拮抗剂或激动剂，并没有改变自然发生的社会偏好的雌性大鼠。刺激特异性社交回避可以通过先前暴露于哺乳期大鼠诱导：这种效应不能被冰冷的OXT逆转/克服。与现有方法的比较：本研究建立的雌性大鼠社会偏好范式发现了大鼠社会偏好行为的细微性别差异。此外，刺激特异性的社会赤字可以诱导雌性大鼠使用急性暴露于社会defeat -如先前观察到的在雄性ratchets.Conclusions：雌性大鼠表现出强烈的社会偏好行为，这可以防止社会失败，但似乎不受调节的OXT或AVP系统。因此，冰冷的应用合成OXT不会逆转母鼠失败诱导的社交回避。(C)2014爱思唯尔有限公司版权所有。
Background: Research concerning non-reproductive sociability in rodents is mainly restricted to assessing the effects of oxytocin (OXT) and arginine-vasopressin (AVP) in male rats and mice. Comparable studies on natural social preference and social avoidance in females are substantially lacking.New method: Here, we adapted a behavioral paradigm for monitoring social preference of female rats consisting of two consecutive exposures to either non-social or social stimuli. Further, to induce stimulus-specific social avoidance, female rats were exposed to a single 10-min maternal defeat by a lactating dam.Results: Social preference towards same-sex conspecifics in female rats was shown to be independent of the estrous cycle and even more pronounced than in male rats. Intracerebroventricular (icy) application of OXT, AVP, or their selective receptor antagonists or agonists, did not alter naturally-occurring social preference in female rats. Stimulus-specific social avoidance could be induced by prior exposure to a lactating rat: an effect that could not be reversed/overcome by icy OXT. Comparison with existing method(s): The female social preference paradigm for rats established in this study detected subtle sex differences in social preference behavior of rats. Further, stimulus-specific social deficits could be induced in female rats using an acute exposure to social defeat - as previously observed in male rodents.Conclusions: Female rats show strong social preference behavior, which can be prevented by social defeat, but does not seem to be regulated by the OXT or AVP systems. Accordingly, icy application of synthetic OXT does not reverse maternal defeat-induced social avoidance in female rats. (C) 2014 Elsevier B.V. All rights reserved.