SALVAGE OF INFARCTED MYOCARDIUM BY ANGIOGENIC ACTION OF BASIC FIBROBLAST GROWTH-FACTOR
SALVAGE OF INFARCTED MYOCARDIUM BY ANGIOGENIC ACTION OF BASIC FIBROBLAST GROWTH-FACTOR
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DOI：
10.1126/science.1382313
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发表时间：
1992-09-04
期刊：
影响因子：
56.9
通讯作者：
ITO, H
中科院分区：
文献类型：
--
作者：
YANAGISAWAMIWA, A;UCHIDA, Y;ITO, H
冠脉侧支血管可减轻冠脉阻塞后对缺血心肌的损伤。刺激侧支循环形成的因素有望对心肌梗死起到改善作用。在犬实验性心肌梗死模型中，冠状动脉内注射碱性成纤维细胞生长因子(BFGF)可改善心脏收缩功能并缩小梗死范围。碱性成纤维细胞生长因子治疗增加了梗死小动脉和毛细血管的数量。因此，碱性成纤维细胞生长因子的血管生成作用可能导致梗塞面积的缩小。碱性成纤维细胞生长因子的应用可能为心肌梗死的抢救提供一种新的治疗途径。
Coronary collateral vessels reduce damage to ischemic myocardium after coronary obstruction. Factors that stimulate collateral formation are expected to have ameliorating effects on myocardial infarction. In a canine experimental myocardial infarct model, intracoronary injection of basic fibroblast growth factor (bFGF) improved cardiac systolic function and reduced infarct size. Treatment with bFGF increased the number of arterioles and capillaries in the infarct. Thus, the angiogenic action of bFGF might lead to a reduction in infarct size. The application of bFGF might bring about a therapeutic modality for the salvage of infarcted myocardium.