Familial Transmission of Hospital-Treated Varicose Veins in Adoptees: A Swedish Family Study
Familial Transmission of Hospital-Treated Varicose Veins in Adoptees: A Swedish Family Study
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DOI：
10.1016/j.jamcollsurg.2016.06.007
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发表时间：
2016-09-01
影响因子：
5.2
通讯作者：
Zoller, Bengt
中科院分区：
文献类型：
--
作者：
Kohno, Kunie;Niihara, Hiroyuki;Zoller, Bengt
背景：静脉曲张（VVs）在家庭中聚集，但在被收养者中VVs的家族风险尚未确定。目的是估计是否VV的家庭传播与疾病的生物和/或adoptive parents.Study设计：瑞典多代登记和瑞典患者登记被用来遵循所有瑞典出生的被收养者（出生于1932年至2004年），可以连接到他们的生物和他们的养父母（n = 80,214，50%女性）。与没有亲生父母或养父母患有VV的被收养人（n = 1，758）相比，至少有一名亲生父母患有VV，但没有养父母患有VV的被收养人（n = 187）估计了VV的风险。还确定了至少有一个养父母但没有亲生父母患有VV的被收养者（n = 87）以及亲生父母和养父母均受影响的被收养者（n = 21）的VV风险。从受影响的亲生父母，但没有养父母，与来自未受影响的亲生父母或养父母的被收养者相比，更有可能发生VV（标准发生率比[SIR] = 2.21; 95% CI，1.91 e2.55）。同时有受影响的亲生父母和养父母的被收养者的家族SIR为4.58（95%CI，2.83-7.01）。与受影响的养父母，但没有亲生父母的被收养者并没有在VV的风险增加（SIR = 1.15; 95%CI，0.92-1.42）。结论：这些新的研究结果表明，遗传因素作出了很大的贡献，家庭传播的VV从父母到后代，虽然家庭环境因素可能作出贡献。(C)2016年美国外科医生学会。爱思唯尔公司出版All rights reserved.
BACKGROUND: Varicose veins (VVs) cluster in families, but the familial risk of VVs has not been determined among adoptees. The aim was to estimate whether the familial transmission of VVs is related to disease in biological and/or adoptive parents.STUDY DESIGN: The Swedish Multi-Generation Register and the Swedish Patient Register were used to follow all Swedish-born adoptees (born 1932 through 2004) that could be linked to both their biological and their adoptive parents (n = 80,214; 50% females). The risk of VVs was estimated in adoptees with at least 1 biological parent with VVs, but no adoptive parent with VVs (n = 187) compared with adoptees without a biological or adoptive parent with VVs (n = 1,758). The risk of VVs was also determined in adoptees with at least 1 adoptive parent, but no biological parent with VVs (n = 87), and in adoptees with both biological and adoptive parents affected (n = 21).RESULTS: Adoptees from an affected biological parent, but no adoptive parent, were more likely to have VVs than adoptees from an unaffected biological or adoptive parent (standard incidence ratio [SIR] = 2.21; 95% CI, 1.91e2.55). The familial SIR for adoptees with both an affected biological parent and an adoptive parent was 4.58 (95% CI, 2.83-7.01). Adoptees with an affected adoptive parent but no biological parent were not at increased risk of VVs (SIR = 1.15; 95% CI, 0.92-1.42).CONCLUSIONS: These novel findings suggest that genetic factors make a strong contribution to the familial transmission of VVs from parents to offspring, although familial environmental factors might contribute. (C) 2016 by the American College of Surgeons. Published by Elsevier Inc. All rights reserved.