Feasibility test of a new method to measure retinal thickness noninvasively.
Feasibility test of a new method to measure retinal thickness noninvasively.
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DOI：
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发表时间：
1989-10
影响因子：
4.4
通讯作者：
Ran Zeimer;M. Mori;Bahram Khoobehi
中科院分区：
文献类型：
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作者：
Ran Zeimer;M. Mori;Bahram Khoobehi
有许多破坏性的眼部疾病与视网膜或神经纤维层厚度的改变直接相关，例如青光眼和黄斑水肿。为了更早地诊断这些疾病并更灵敏地监测其治疗，需要精确测量组织厚度。由于目前没有临床方法可用，我们开发并测试了一种能够非侵入性测量视网膜厚度的新方法。通过光电系统量化前后交叉点的图像之间的分离。计算了该方法的理论性能。该方法在模型眼中的测试表明，测量基本上是衍射限制的，其再现性为+/-9微米，其精度为5.5微米。在体内进行的测试表明，激光和视网膜之间存在两个交叉点，对应于视网膜的前表面和后表面。这些交叉点可以被解析和分析以产生定量数据。这些令人鼓舞的结果表明，这种方法是可行的，可以产生灵敏的测量视网膜厚度。
There are many devastating ocular diseases that are directly related to an alteration of the retinal or nerve fiber layer thickness, such as glaucoma and macular edema. To diagnose these diseases earlier and to monitor their therapy more sensitively, an accurate measurement of the tissue thickness is needed. Since no clinical method is currently available, we developed and tested a new method capable of measuring noninvasively the retinal thickness. The separation between the images of the anterior and posterior intersections is quantitated by an optoelectronic system. The theoretical performance of the method has been calculated. Tests of the method in a model eye indicated that the measurements were basically diffraction limited, their reproductivity was +/- 9 microns, and their accuracy was 5.5 microns. Tests performed in vivo indicated that two intersections between the laser and the retina are present and correspond to the anterior and posterior surfaces of the retina. These intersections can be resolved and analyzed to yield quantitative data. These encouraging results indicate that this method is feasible and could yield sensitive measurements of the retinal thickness.