Deep origin of plastid/parasite ATP/ADP translocases
Deep origin of plastid/parasite ATP/ADP translocases
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DOI：
10.1007/s00239-002-2387-0
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发表时间：
2003-02-01
影响因子：
3.9
通讯作者：
Andersson, SGE
中科院分区：
文献类型：
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作者：
Amiri, H;Karlberg, O;Andersson, SGE
在线粒体、质体和专性细胞内寄生虫中已经发现了运输ATP和ADP的膜蛋白。线粒体ATP/ADP转运蛋白来自真核起源的广泛特异性转运家族，而质体/寄生虫ATP/ADP转运酶的起源则更加难以捉摸。本文介绍了4种立克次体中编码ATP/ADP转位的5个基因序列。结果与立克次体谱系中5个ATP/ADP易位的早期重复和分化一致。线粒体和质体/寄生虫ATP/ADP转座的系统发育深度比较表明，这两种转运体都有很深的起源。结果没有提供证据表明立克次体最近通过水平基因转移获得ATP/ADP转运体，如先前所建议的那样。两种类型的ATP/ADP转座的可能功能是允许早期真核细胞及其内共生体在糖酵解和有氧呼吸之间切换。
Membrane proteins that transport ATP and ADP have been identified in mitochondria, plastids, and obligate intracellular parasites. The mitochondrial ATP/ADP transporters are derived from a broad-specificity transport family of eukaryotic origin, whereas the origin of the plastid/parasite ATP/ADP translocase is more elusive. Here we present the sequences of five genes coding for ATP/ADP translocases from four species of Rickettsia. The results are consistent with an early duplication and divergence of the five ATP/ADP translocases within the rickettsial lineage. A comparison of the phylogenetic depths of the mitochondrial and the plastid/parasite ATP/ADP translocases indicates a deep origin for both transporters. The results provide no evidence for a recent acquisition of the ATP/ADP transporters in Rickettsia via horizontal gene transfer, as previously suggested. A possible function of the two types of ATP/ADP translocases was to allow switches between glycolysis and aerobic respiration in the early eukaryotic cell and its endosymbiont.