Constitutional trisomy 8 mosaicism with myelodysplastic syndrome complicated by intestinal Behcet disease and antithrombin III deficiency
Constitutional trisomy 8 mosaicism with myelodysplastic syndrome complicated by intestinal Behcet disease and antithrombin III deficiency
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DOI：
10.1016/j.cancergencyto.2005.01.010
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发表时间：
2005-10-15
影响因子：
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通讯作者：
Ruhnke, GW
中科院分区：
文献类型：
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作者：
Ando, S;Maemori, M;Ruhnke, GW
8 三体是与骨髓恶性肿瘤相关的最常见的获得性染色体异常。作为一种宪法三体性嵌合体（T8M），它表现出极其可变的表型。此外，白塞氏病 (1313) 据报道是骨髓增生异常综合征 (MDS) 的一种罕见并发症。据我们所知，迄今为止已发表 12 例 T8M 患者各种血液恶性肿瘤的病例报告和 18 例获得性 8 三体性 MDS 并发 BD 患者的病例报告。我们报告了一例伴有 MDS 的体质性 T8M 并发肠道 BD 和抗凝血酶 III 缺乏症的病例。 (c) 2005 Elsevier Inc. 保留所有权利。
Trisomy 8 is the most common acquired chromosomal abnormality associated with myeloid malignancy. As a constitutional trisomy 8 mosaicism (T8M), it exhibits an extremely variable phenotype. In addition, Behcet disease (1313) has been reported as an unusual complication of myelodysplastic syndrome (MDS). To our knowledge, 12 case reports of various hematologic malignancies in patients with T8M and 18 case reports of MDS with acquired trisomy 8 complicated by BD have been published to date. We report a case of constitutional T8M with MDS complicated by intestinal BD and antithrombin III deficiency. (c) 2005 Elsevier Inc. All rights reserved.