ORIGIN OF NEOCORTICALLY MONITORED THETA RHYTHM IN CURARIZED RAT
ORIGIN OF NEOCORTICALLY MONITORED THETA RHYTHM IN CURARIZED RAT
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DOI：
10.1016/0013-4694(78)90290-0
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发表时间：
1978-01-01
期刊：
影响因子：
--
通讯作者：
LLOYD, RL
中科院分区：
文献类型：
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作者：
GERBRANDT, LK;LAWRENCE, JC;LLOYD, RL
在普鲁卡因局部麻醉和D-筒箭毒的大鼠中急性植入硬膜外电极阵列，以绘制新皮层内出现的节律性慢活动（RSA）的表面分布。峰值振幅（约122 μ V）集中在背侧海马轮廓上。在新皮质内记录的RSA的层状轮廓表明相对于同向硬膜外电极没有相位变化。RSA的幅度略有增加（平均增加= 53%），在最深层次的新皮层，但它并没有接近一个振幅峰值或零内的新皮层。新皮层内的多单位活动并不与RSA相锁定。当电极进入背侧海马体时，观察到RSA发生器的所有这些表现。单侧皮质扩散性抑制（CSD）治疗，显着衰减巴比妥类纺锤体在所有10名受试者，通常（7 10）对新皮质监测RSA没有影响。抑郁和非抑郁半球之间的分离，以及新皮层和海马RSA之间，在CSD期间获得了一些科目。同时分离也明显记录网站之间的海马。大鼠的新皮质RSA被动地从底层海马扩散，在大鼠的新皮质和海马RSA的解离是继发于海马RSA的多个发电机的组织变化。
An array of epidural electrodes was acutely implanted in locally anesthetized with procaine and curarized with D-tubocurarine rats to map the surface distribution of rhythmic slow activity (RSA) which appeared within the neocortex. Peak amplitudes (of about 122 .mu.V) were centered over the dorsal hippocampus outline. A laminar profile of RSA recorded within the neocortex indicated no shifts in phase relative to a homotopic, epidural electrode. RSA increased slightly in amplitude (mean increase = 53%) at the deepest level of neocortex, but it did not approximate an amplitude peak or null within the neocortex. Multiple-unit activities within the neocortex were not phase-locked to RSA. All of these manifestations of an RSA generator were observed as electrodes passed into the dorsal hippocampus. A unilateral cortical spreading depression (CSD) treatment, which markedly attenuated barbiturate spindles in all 10 subjects, usually (7 of 10) had no effect on the neocortically monitored RSA. Dissociations between depressed and non-depressed hemispheres, and between neocortical and hippocampal RSA, were obtained in some subjects during CSD. Concurrent dissociations were also apparent between recording sites within the hippocampus. The neocortical RSA of rats was passively spread from the underlying hippocampus, and dissociations in neocortical and hippocampal RSA in the rat were secondary to changes in the organization of multiple generators of hippocampal RSA.