THE MESSENGER-RNA LEVELS OF THYROTROPIN RECEPTOR, THYROGLOBULIN AND THYROID PEROXIDASE IN NEOPLASTIC HUMAN THYROID TISSUES
THE MESSENGER-RNA LEVELS OF THYROTROPIN RECEPTOR, THYROGLOBULIN AND THYROID PEROXIDASE IN NEOPLASTIC HUMAN THYROID TISSUES
复制标题
DOI：
10.1016/0006-291x(91)91540-s
复制
发表时间：
1991-02-14
影响因子：
3.1
通讯作者：
ONAYA, T
中科院分区：
文献类型：
--
作者：
OHTA, K;ENDO, T;ONAYA, T
应用Northern-blot和Slot-blot方法检测了6例甲状腺腺瘤和7例甲状腺癌组织中促甲状腺激素受体（TSH-R）、甲状腺球蛋白（Tg）和甲状腺过氧化物酶（TPO）mRNA的表达水平。结果发现，癌组织中TSH-R mRNA水平明显低于正常组织。与正常组织相比，腺瘤和癌组织中Tg mRNA的水平也显著降低。与此相反，没有观察到这些组织之间的TPO mRNA的表达水平的显着差异。此外，肿瘤组织中TSH-R mRNA水平与Tg mRNA水平具有良好的相关性。这些结果表明，TSH-R和Tg的mRNA表达与其分化程度有关。
Expression levels of thyrotropin receptor (TSH-R), thyroglobulin (Tg) and thyroid peroxidase (TPO) mRNA in normal and neoplastic human thyroid tissues (6 adenomas and 7 carcinomas) were investigated by Northern-blot and slot-blot analyses. We found that TSH-R mRNA levels were significantly lower in carcinoma tissues than in normal tissues. The levels of Tg mRNA were also significantly lowered in adenoma and carcinoma tissues as compared to normal tissues. In contrast, no significant difference was observed in the expression levels of TPO mRNA between these tissues. Furthermore, TSH-R mRNA levels were well-correlated with Tg mRNA levels in neoplastic tissues. These results suggest that mRNAs of TSH-R and Tg are expressed in relation to their degree of differentiation.