Is diabetic retinopathy an independent risk factor for ischemic stroke?
Is diabetic retinopathy an independent risk factor for ischemic stroke?
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DOI：
10.1161/01.str.0000254547.91276.50
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发表时间：
2007-02-01
期刊：
影响因子：
8.3
通讯作者：
Wong, Tien Y.
中科院分区：
文献类型：
--
作者：
Cheung, Ning;Rogers, Sophie;Wong, Tien Y.
背景和目的：糖尿病视网膜病变和缺血性卒中之间的关系尚不确定，本研究对其进行了研究。方法：对1617例中年糖尿病患者进行了一项基于人群的前瞻性队列研究。糖尿病视网膜病变的迹象，确定视网膜照片，缺血性中风事件的前瞻性识别和验证。结果-在平均7.8年的随访中，有75例缺血性卒中事件。在校正年龄、性别、种族、中心、6年平均动脉血压、抗高血压治疗使用、空腹血糖、胰岛素治疗、糖尿病病程、高密度脂蛋白和低密度脂蛋白胆固醇水平以及吸烟状况后，糖尿病视网膜病变与缺血性卒中风险增加相关（风险率比，2.34; 95% CI，1.13 - 4.86）。结论：糖尿病视网膜病变可预测糖尿病患者缺血性卒中的发生，与其他危险因素无关。（中风。2007;38：398-401）。
Background and Purpose-The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. Methods-A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated. Results-Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86). Conclusions-Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors. (Stroke. 2007;38:398-401.)