High peritumoral Bmi-1 expression is an independent prognosticator of poor prognosis in renal cell carcinoma
High peritumoral Bmi-1 expression is an independent prognosticator of poor prognosis in renal cell carcinoma
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瘤周 Bmi-1 高表达是肾细胞癌预后不良的独立预测因素
DOI：
10.1007/s13277-015-3525-9
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发表时间：
2015-09-01
期刊：
影响因子：
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通讯作者：
Guo, Jianming
中科院分区：
文献类型：
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作者：
Long, Qilai;Liu, Li;Guo, Jianming
B淋巴瘤Mo-MLV插入区1同源物（Bmi-1）是一种转录抑制因子，在肿瘤的发生发展中起重要作用，但Bmi-1在肾脏肿瘤发生中的功能及其预后价值尚不清楚。本研究旨在探讨肾细胞癌患者瘤内及瘤周Bmi-1表达的预后价值。采用免疫组织化学方法对2005 ~ 2007年中山医院行根治性肾切除术的241例患者的成对肿瘤及瘤周肾组织标本中Bmi-1的表达进行了测定。研究Bmi-1表达与临床、病理参数及预后的关系。Bmi-1在瘤周和瘤内组织均有特异性表达。Bmi-1在肿瘤周围而非肿瘤内的高表达与较差的总生存期（OS） （P < 0.001）和无复发生存期（RFS） （P = 0.003）显著相关。此外，Bmi-1表达被确定为OS的独立预后因素，并且结合肿瘤周围Bmi-1和肿瘤淋巴结转移（TNM）分期可以更好地预测患者的死亡和疾病复发。肿瘤周围高表达的Bmi-1可以作为一种独立的预后生物标志物，并可能成为肾细胞癌（RCC）的新治疗靶点。
B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is a transcriptional repressor, which plays important roles in the development of cancers, but the function of Bmi-1 in kidney tumorigenesis and its prognostic values remain unclear. This study aims to investigate prognostic values of the intratumoral and peritumoral expression of Bmi-1 in patients with renal cell carcinoma. Expression of Bmi-1 was assessed by immunohistochemistry in specimens containing paired tumor and peritumoral renal tissue from 241 patients who had undergone curative nephrectomy at Zhongshan Hospital from 2005 to 2007. The association of Bmi-1 expression with clinical and pathological parameters and outcomes was investigated. Specific expression of Bmi-1 was found both in peritumoral and intratumoral tissues. High expression of Bmi-1 in peritumoral but not intratumoral is significantly associated with poor overall survival (OS) (P < 0.001) and relapse-free survival (RFS) (P = 0.003). Furthermore, Bmi-1 expression was identified as an independent prognostic factor for OS, and combination of peritumoral Bmi-1 and tumor node metastasis (TNM) stage had a better power to predict the patients' death and disease recurrence. High peritumoral Bmi-1 expression can serve as an independent prognostic biomarker and could be a novel therapeutic target for renal cell carcinoma (RCC).