The sequence and structure of a new serum amyloid A gene.
The sequence and structure of a new serum amyloid A gene.
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新血清淀粉样蛋白 A 基因的序列和结构。
DOI：
10.1093/nar/14.2.797
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发表时间：
1986
影响因子：
14.9
通讯作者：
Morrow,JF
中科院分区：
文献类型：
--
作者：
Stearman,RS;Lowell,CA;Peltzman,CG;Morrow,JF
急性期反应的特征在于许多蛋白质的血清浓度的变化。小鼠注射LPS后24小时内，血清淀粉样蛋白A（SAA）浓度增加1000倍。我们已经分离出一个cDHA克隆和其相应的基因组噬菌体的第三个，以前未报道的SAA蛋白。cDNA序列、基因外显子和邻近的DHA沿着支持基因结构的作图证据。
The acute phase response is characterized by changes in the serum concentrations of many proteins. A 1000-fold increase in the concentration of ssrum amyloid A (SAA) protein occurs within 24 hours of LPS injection in the mouse. We have isolated a cDHA clone and its corresponding genomic phage for a third, previously unreported SAA protein. The sequences of the cDNA, the gene's exons and neighboring DHA are presented along with the mapping evidence supporting the gene structure.