Evidence of neuroinflammation in fibromyalgia syndrome: a [ 18 F]DPA-714 positron emission tomography study.
Evidence of neuroinflammation in fibromyalgia syndrome: a [ 18 F]DPA-714 positron emission tomography study.
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DOI：
10.1097/j.pain.0000000000002927
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发表时间：
2023-10-01
期刊：
影响因子：
7.4
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中科院分区：
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我们发现，与健康对照组相比，纤维肌痛患者的几个脑区中转运蛋白放射性配体[18F]DPA-714的结合增加。这项观察性研究旨在确定纤维肌痛（FM）患者是否表现出比健康对照（HC）更高水平的神经炎症，这是使用[18 F]DPA-714（转运蛋白的第二代放射性配体）进行正电子发射断层扫描测量的（TSPO）。15名患有FM和10名HC的女性接受了神经影像学检查。使用Logan图形分析计算28个感兴趣区域（ROI）的分布容积（VT），并使用多重线性回归进行组间比较。组（FM vs HC）是关注的主要预测因子，TSPO结合状态（高亲和力vs混合亲和力）作为协变量添加。FM组右侧中央后回（B = 0.477，P = 0.033）、右侧枕叶灰质（GM; B = 0.438，P = 0.039）和右侧颞叶GM（B = 0.466，P = 0.042）的VT较高。在扣带回左侧峡部，FM组的VT也低于HC组（B =-0.553，P = 0.014）。在高亲和力结合者的亚组中，FM组在双侧楔前叶、中央后回、顶叶GM、枕叶GM和缘上回有较高的VT。右顶叶GM的组间差异与生活质量下降、疼痛严重程度和干扰程度增加以及认知问题有关。在支持我们的假设，我们发现增加放射性配体结合（VT）在FM组相比，HC在几个大脑区域，无论参与者的TSPO结合状态。ROI与之前FM中TSPO结合增加的报告重叠。总的来说，越来越多的证据支持FM涉及大脑中小胶质细胞介导的神经炎症的假设。
We found increased binding of the translocator protein radioligand [18F]DPA-714 in several brain regions in fibromyalgia patients compared with healthy controls. This observational study aimed to determine whether individuals with fibromyalgia (FM) exhibit higher levels of neuroinflammation than healthy controls (HCs), as measured with positron emission tomography using [18F]DPA-714, a second-generation radioligand for the translocator protein (TSPO). Fifteen women with FM and 10 HCs underwent neuroimaging. Distribution volume (VT) was calculated for in 28 regions of interest (ROIs) using Logan graphical analysis and compared between groups using multiple linear regressions. Group (FM vs HC) was the main predictor of interest and TSPO binding status (high- vs mixed-affinity) was added as a covariate. The FM group had higher VT in the right postcentral gyrus (b = 0.477, P = 0.033), right occipital gray matter (GM; b = 0.438, P = 0.039), and the right temporal GM (b = 0.466, P = 0.042). The FM group also had lower VT than HCs in the left isthmus of the cingulate gyrus (b = −0.553, P = 0.014). In the subgroup of high-affinity binders, the FM group had higher VT in the bilateral precuneus, postcentral gyrus, parietal GM, occipital GM, and supramarginal gyrus. Group differences in the right parietal GM were associated with decreased quality of life, higher pain severity and interference, and cognitive problems. In support of our hypothesis, we found increased radioligand binding (VT) in the FM group compared with HCs in several brain regions regardless of participants' TSPO binding status. The ROIs overlapped with prior reports of increased TSPO binding in FM. Overall, increasing evidence supports the hypothesis that FM involves microglia-mediated neuroinflammation in the brain.
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DOI：
10.1016/j.bbi.2018.09.018
发表时间：
2019-01
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
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DOI：
10.1007/s00259-019-04662-4
发表时间：
2020-08-01
影响因子：
9.1
作者：
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通讯作者：
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影响因子：
14.5
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影响因子：
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CHRISTMAN, DR
影响因子：
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通讯作者：
Fischl, Bruce