Obesity and disease management: Effects of weight loss on comorbid conditions
Obesity and disease management: Effects of weight loss on comorbid conditions
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DOI：
10.1038/oby.2001.138
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发表时间：
2001-11-01
期刊：
影响因子：
--
通讯作者：
Konz, EC
中科院分区：
文献类型：
--
作者：
Anderson, JW;Konz, EC
目的：本综述旨在量化肥胖和体重增加对冠心病风险的影响，并综述体重减轻对冠心病危险因素的影响。研究方法和步骤：在全面回顾体重和体重增加对冠心病风险的相关文献后，列出相对风险(RR)。结果：体重指数值较高的年轻人患冠心病的风险明显高于身材苗条的年轻人。体重指数每增加1%，女性患冠心病的风险就增加3.3%，男性增加3.6%。高中毕业后体重每增加一公斤，女性患冠心病的风险增加5.7%，男性增加3.1%。体重减轻显著降低了冠心病的主要危险因素。每减轻一公斤体重，就会出现以下有利的变化：空腹血清胆固醇-1.0%；低密度脂蛋白胆固醇-0.7%；甘油三酯-1.9%；高密度脂蛋白胆固醇-0.2%；收缩压-0.5%；舒张压-0.4%；血糖-0.2 mm。讨论：肥胖和/或体重增加与冠心病的主要风险相关。减肥显著改善血脂参数、血压和空腹血糖值。对于大多数超重或肥胖的人来说，有效的治疗方法是可用的，但一个主要的挑战是使这些人能够参与这些计划。专业和消费者教育对于推进针对超重个体的有效干预策略至关重要。
Objective: This review is designed to quantitate the effects of obesity and weight gain on risk for coronary heart disease (CHD) and to review the effects of weight loss on CHD risk factors.Research Methods and Procedures: After a comprehensive review of the literature related to body weight and weight gain on CHD risk, the relative risks (RRs) were tabulated. Values were averaged and meta-analysis techniques were used to estimate the variance-adjusted RR.Results: Young persons with higher body mass index values have a significantly higher risk for CHD than do slender young people. For every 1% above a desirable body mass index, the risk for CHD increases by 3.3% for women and by 3.6% for men. Every kilogram of weight gain after high school increases risk for CHD by 5.7% for women and 3.1% for men. Weight loss significantly decreases major CHD risk factors. For every kilogram of weight loss the following favorable changes occur: fasting serum cholesterol, -1.0%; low-density lipoprotein cholesterol, -0.7%; triglycerides, -1.9%; high-density lipoprotein cholesterol, +0.2%; systolic blood pressure, -0.5%; diastolic blood pressure, -0.4%; and blood glucose, -0.2 mM.Discussion: Obesity and/or weight gain are associated with major risk for CHD. Weight loss significantly improves serum lipid parameters, blood pressure, and fasting blood glucose values. Effective treatment approaches are available for most overweight or obese individuals but a major challenge is to enable these individuals to engage in these programs. Professional and consumer education is essential for advancing effective intervention strategies for overweight individuals.