Regional Cerebral Arterial Transit Time Hemodynamics Correlate with Vascular Risk Factors and Cognitive Function in Men with Coronary Artery Disease
Regional Cerebral Arterial Transit Time Hemodynamics Correlate with Vascular Risk Factors and Cognitive Function in Men with Coronary Artery Disease
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DOI：
10.3174/ajnr.a4094
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发表时间：
2015-02-01
影响因子：
3.5
通讯作者：
Lanctot, K. L.
中科院分区：
文献类型：
--
作者：
MacIntosh, B. J.;Swardfager, W.;Lanctot, K. L.
背景和目的：动脉转运时间是血液从大动脉到毛细血管所需的时间，根据动脉自旋标记磁共振成像估计。这项研究的目的是确定血管危险因素和认知能力是否与有认知下降风险的冠心病患者脑动脉通过时间的地区差异有关。材料和方法：从29名冠心病患者获得的多个标记后延迟伪连续动脉自旋标记图像估计动脉通过时间。进行了记忆力、注意力、处理速度和执行功能测试。结果：主成分分析确定了血管风险的2个成分：1)“血压”(年龄、收缩压和脉压)和2)“肥胖”(体脂百分比和身体质量指数)。肥胖与后扣带回、楔前叶、枕叶外侧皮质、颞中回和额叶的动脉通过时间呈负相关(P校正后，P<0.05)，而升压作用不显著。认知分数被分解成一个单独的组成部分。表现不佳与楔前动脉通过时间呈负相关(P<0.05)。肥胖识别区域的平均动脉通过时间与认知功能较差有关(r(2)=0.21，t=-2.65，P=0.01)。结论：脑血流动力学改变，特别是默认模式网络的结节结构，可能是血管危险因素影响冠心病患者认知功能的一种方式。
BACKGROUND AND PURPOSE: Arterial transit time is the time needed for blood to travel from large arteries to capillaries, as estimated from arterial spin-labeling MR imaging. The purpose of this study was to determine whether vascular risk factors and cognitive performance are related to regional differences in cerebral arterial transit time in patients with coronary artery disease who are at risk for cognitive decline.MATERIALS AND METHODS: Arterial transit time was estimated from multiple postlabel delay pseudocontinuous arterial spin-labeling images obtained from 29 men with coronary artery disease. Tests of memory, attention, processing speed, and executive function were administered. Principal component analysis was used to create separate models of cognition and vascular risk, which were related to brain regions through voxelwise analyses of arterial transit time maps.RESULTS: Principal component analysis identified 2 components of vascular risk: 1) "pressor" (age, systolic blood pressure, and pulse pressure) and 2) "obesity" (body fat percentage and body mass index). Obesity was inversely related to arterial transit time in the posterior cingulate, precuneus, lateral occipital cortices, middle temporal gyrus, and frontal pole (P corrected < .05), whereas pressor was not significant. Cognitive scores were factored into a single component. Poor performance was inversely related to precuneus arterial transit time (P corrected < .05). The average arterial transit time in regions identified by obesity was associated with poorer cognitive function (r(2) = 0.21, t = -2.65, P = .01).CONCLUSIONS: Altered cerebral hemodynamics, notably in nodal structures of the default mode network, may be one way that vascular risk factors impact cognition in patients with coronary artery disease.