Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man
Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man
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关于疼痛的研究。
DOI：
10.1016/0006-8993(85)90719-x
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发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
J. Willer
中科院分区：
文献类型：
--
作者：
J. Willer
对6名健康志愿者进行了腓肠神经刺激诱发的伤害性屈曲反射及相应的疼痛评分的研究。一个显着的相关性被发现之间的反射和疼痛评分作为刺激强度的函数的各自的招聘曲线。因此，发现反射（Tr）和疼痛（Tp）阈值几乎相同（平均值：分别为10.6和10.3 mA）。同样，阈值的最大反射反应（TMR）是非常接近的，不能忍受的疼痛（提示）：37.1和38.8 mA，分别这四个参数进行了研究之前和之后，静脉注射盐酸吗啡（0.05，0.1，0.2和0.3 mg/kg）和盐酸纳洛酮（0.02 mg/kg; i. v.）。虽然0.05 mg/kg吗啡仍然没有任何影响，但更高的剂量产生了四个阈值（Tr，Tp，Tmr，Tip）的增加。此外，一个非常显着的线性关系之间的重要性的增加和吗啡的剂量。吗啡也以剂量依赖的方式抑制由恒定刺激强度（1.2- 1.3Tr）引起的伤害性反射。在所有药理学情况下，Trand Tpas和Tmrand Tip的变化均呈非常显著的线性相关，表明吗啡对伤害性反射的影响与对相关疼痛感觉的影响之间存在密切关系。这些结果表明，在我们的模型中，涉及一个简短的“epicritic”伤害性刺激，吗啡诱导镇痛的机制，在男人可以解释由一个抑制效应的伤害性传递直接在脊髓水平。
The nociceptive flexion reflex and the corresponding subjective pain score elicited by sural nerve stimulation were studied in 6 healthy volunteers. A significant correlation was found between the respective recruitment curves of the reflex and of the pain score as a function of stimulus intensity. Consequently, the reflex (Tr) and the pain (Tp) thresholds were found to be almost identical (mean: 10.6 and 10.3 mA, respectively). Similarly, the threshold of the maximal reflex response (Tmr) was very close to that of intolerable pain (Tip): 37.1 and 38.8 mA, respectively.These four parameters were studied before and after intravenous administration of morphine chlorhydrate (0.05, 0.1, 0.2 and 0.3 mg/kg) and subsequent administration of naloxone hydrochloride (0.02 mg/kg; i.v.). While 0.05 mg/kg morphine remained without any effect, higher doses produced an increase in the four thresholds (Tr, Tp, Tmr, Tip). Furthermore, a very significant linear relationship was found between the importance of the increase and the dose of morphine. Morphine also depressed in a dose-dependent fashion, the nociceptive reflexes elicited by a constant stimulation intensity (1.2–1.3 Tr). All these effects were immediately reversed by subsequent naloxone.During all the pharmacological situations, variations in Trand Tpas well as in Tmrand Tipwere found to be very significantly linearly related, indicating a close relationship between the effects of morphine on the nociceptive reflex and on the related pain sensation. These results suggest that, in our model involving a brief ‘epicritic’ nociceptive stimulus, the mechanisms of morphine-induced analgesia in man can be explained by a depressive effect on the nociceptive transmission directly at a spinal level.