Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women
Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women
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DOI：
10.1210/jc.86.2.631
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发表时间：
2001-02-01
影响因子：
5.8
通讯作者：
Cummings, SR
中科院分区：
文献类型：
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作者：
Browner, WS;Lui, LY;Cummings, SR
骨保护素(OPG)及其配体是调节破骨细胞生成的细胞因子，可能参与血管钙化的调节。我们研究了血清OPG水平是否与中风、死亡率和包括糖尿病在内的心血管危险因素有关，以及与骨密度和骨折之间的关系，在一组年龄在65岁以上的白人女性中抽取了490名受试者。我们发现，糖尿病患者的血清OPG水平(平均+/-SD，0.30+/-0.17 ng/m L)比非糖尿病女性(0.23+/-0.10 ng/m L；P=0.0001)高约30%。OPG水平与死因死亡率[年龄调整的优势比，血清OPG水平增加1.4/SD(0.11 ng/ml)；95%可信区间，1.2-1.8]和心血管死亡率(优势比，1.4；95%可信区间，1.1-1.8)相关；这些影响不会被糖尿病混淆。OPG水平与基线骨密度或随后的中风或骨折无关。血清OPG水平与糖尿病和心血管死亡率的相关性增加了OPG可能是血管钙化的原因或标志的可能性。
Osteoprotegerin (OPG) and its ligand are cytokines that regulate osteoclastogenesis and that may be involved in the regulation of vascular calcification. We examined whether serum OPG levels were associated with stroke, mortality, and cardiovascular risk factors, including diabetes, as well as with bone mineral density and fractures in a sample of 490 participants in a prospective cohort of white women, at least 65 yr of age. We found that OPG levels, assayed blinded from serum obtained at baseline, were about 30% greater in women with diabetes (mean +/- SD, 0.30 +/- 0.17 ng/mL) than in those without diabetes (0.23 +/- 0.10 ng/mL; P = 0.0001). OPG levels were associated with ah-cause mortality [age-adjusted odds ratio, 1.4/SD (0.11 ng/mL) increase in serum OPG level; 95% confidence interval, 1.2-1.8] and cardiovascular mortality (odds ratio, 1.4; 95% confidence interval, 1.1-1.8); these effects were not confounded by diabetes. OPG levels were not associated with baseline bone mineral density or with subsequent strokes or fractures. The association of serum OPG levels with diabetes and with cardiovascular mortality raises the possibility that OPG may be a cause of or a marker for Vascular calcification.