Anemia and hemoglobinopathies in Southeast Asian refugee children.
Anemia and hemoglobinopathies in Southeast Asian refugee children.
复制标题
东南亚难民儿童的贫血和血红蛋白病。
DOI：
10.1016/s0022-3476(83)80235-2
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Lubin,BH
中科院分区：
文献类型：
--
作者：
Hurst,D;Tittle,B;Kleman,KM;Embury,SH;Lubin,BH
本文报告163个家庭254名东南亚难民儿童的血液学检查结果，血红蛋白E性状在越南人和老挝人中常见（19%和18%），而在越南人中少见（1%）。β-地中海贫血在越南人中最常见（8%），在老挝人和老挝人中较不常见（3%）。α-地中海贫血在所有三组中均普遍存在。将血红蛋白病患儿的血红蛋白浓度和平均红细胞体积与东南亚血红蛋白正常儿童进行比较。Hb AE和Hb EE均显示为良性疾病，导致小红细胞增多和轻度贫血（如果有）。在Hb AE儿童中，平均红细胞体积范围为64至78 fl，Hb E为27%至34%。在Hb EE患者中，小红细胞增多更为明显（50至63 fl）。在15名患有Hb EE的儿童中，胎儿血红蛋白下降延迟，这可能导致婴儿诊断困难。
Hematologic evaluations of 254 Southeast Asian refugee children from 163 families are reported.Hemoglobin E trait was common in Cambodians (19%) and Laotians (18%), but rare in Vietnamese (1%). β-Thalassemia trait was most prevalent in Vietnamese (8%), and less common in Cambodians and Laotians (3%). α-Thalassemia was prevalent in all three groups. Hemoglobin concentrations and mean corpuscular volumes seen with hemoglobinopathies were compared with those of Southeast Asian children with normal hemoglobin. Both Hb AE and Hb EE were shown to be benign conditions resulting in microcytosis and mild, if any, anemia. In children with Hb AE, mean corpuscular volume ranged from 64 to 78 fl and Hb E from 27% to 34%. In those with Hb EE, microcytosis was more marked (50 to 63 fl). In 15 children with Hb EE, there was a delayed fall in fetal hemoglobin, which can cause diagnostic difficulties in infants.