Review: Capripoxvirus Diseases: Current Status and Opportunities for Control.
Review: Capripoxvirus Diseases: Current Status and Opportunities for Control.
复制标题
DOI：
10.1111/tbed.12444
复制
发表时间：
2017-06
影响因子：
4.3
通讯作者：
Babiuk LA
中科院分区：
文献类型：
--
作者：
Tuppurainen ESM;Venter EH;Shisler JL;Gari G;Mekonnen GA;Juleff N;Lyons NA;De Clercq K;Upton C;Bowden TR;Babiuk S;Babiuk LA
疙瘩性皮肤病、绵羊痘和山羊痘是家畜反刍动物的高影响疾病，对流行地区的牛、绵羊和山羊养殖业造成毁灭性影响。在本文中，我们回顾了目前的地理分布、疫情的经济影响、流行病学、传播和免疫。本文的特别重点是审查现有疫苗的使用情况，以调查资源需求和为改善疾病控制和根除所必须克服的挑战，以及在开发更安全和更有效的疫苗方面取得的进展。此外，还讨论了疫苗效力的实地评价和痘病毒基因组数据库。
Lumpy skin disease, sheeppox and goatpox are high‐impact diseases of domestic ruminants with a devastating effect on cattle, sheep and goat farming industries in endemic regions. In this article, we review the current geographical distribution, economic impact of an outbreak, epidemiology, transmission and immunity of capripoxvirus. The special focus of the article is to scrutinize the use of currently available vaccines to investigate the resource needs and challenges that will have to be overcome to improve disease control and eradication, and progress on the development of safer and more effective vaccines. In addition, field evaluation of the efficacy of the vaccines and the genomic database available for poxviruses are discussed.