Novel dihydropyridine thioglycosides and their corresponding dehydrogenated forms as potent anti-hepatocellular carcinoma agents
Novel dihydropyridine thioglycosides and their corresponding dehydrogenated forms as potent anti-hepatocellular carcinoma agents
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DOI：
10.1080/15257770.2018.1457161
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发表时间：
2018-01-01
影响因子：
1.3
通讯作者：
El-Naggar, Dina H.
中科院分区：
文献类型：
--
作者：
Elgemeie, Galal H.;El-Naggar, Dina H.
研究了一种通过二氢吡啶硫酮哌啶鎓盐与 2,3,4,6-四-O-乙酰基--D-葡萄糖-和吡喃半乳糖基溴反应制备新型二氢吡啶硫代糖苷及其相应脱氢形式的新方法。对二氢吡啶硫代糖苷和吡啶硫代糖苷对HepG-2细胞系（肝癌细胞系）的抗增殖活性的评估表明，许多硫代糖苷具有有趣的抗肿瘤活性，特别是5c、5g、5l、5o、5p、7a、7i、7p、8b、8f、8s和8v。
A novel method for preparation of a new class of dihydropyridine thioglycosides and their corresponding dehydrogenated forms, via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra-O-acetyl--D-gluco- and galactopyranosyl bromides has been studied. The evaluation of antiproliferative activity against HepG-2 cell lines (liver carcinoma cell lines) of the dihydropyridine thioglycosides and pyridine thioglycosides revealed that many of the thioglycosides have interesting antitumor activities specifically 5c, 5g, 5l, 5o, 5p, 7a, 7i, 7p, 8b, 8f, 8s, and 8v.