Neutrophils, dendritic cells and Toxoplasma
Neutrophils, dendritic cells and Toxoplasma
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DOI：
10.1016/j.ijpara.2003.11.001
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发表时间：
2004-03-09
影响因子：
4
通讯作者：
Bennouna, S
中科院分区：
文献类型：
--
作者：
Denkers, EY;Butcher, BA;Bennouna, S
刚地弓形虫能迅速引发强烈的基于1型细胞因子的免疫反应。干扰素 -γ和白细胞介素 - 12基因敲除小鼠迅速死于急性感染这一实例很好地说明了这种免疫反应的必要性。寄生虫本身善于在先天免疫系统中引发复杂的相互作用，从而产生保护性免疫。中性粒细胞是最早到达感染部位的细胞类型之一，这些细胞会针对弓形虫释放几种促炎细胞因子和趋化因子。树突状细胞是在刚地弓形虫及其他微生物病原体感染过程中白细胞介素 - 12的一个重要来源，并且它们还专门用于向T淋巴细胞进行高效的抗原呈递。速殖子至少表达两种能触发先天免疫细胞产生细胞因子的分子。其中一种涉及许多微生物病原体共有的Toll样受体/髓样分化因子88（MyD88）通路。第二种通路不太常规，涉及寄生虫亲环蛋白与宿主CC趋化因子受体5结合配体之间的分子模拟。中性粒细胞、树突状细胞和弓形虫共同作用以引发宿主生存所需的免疫反应。寄生虫触发的中性粒细胞和树突状细胞之间的细胞因子和趋化因子相互作用导致后者的募集、成熟和激活。得到中性粒细胞助力的树突状细胞具备高效抗原呈递细胞所应有的特性，能够驱动1型辅助性T细胞（Th1）的产生。（C）2003年澳大利亚寄生虫学学会。由爱思唯尔有限公司出版。保留所有权利。
Toxoplasma gondi rapidly elicits strong Type 1 cytokine-based immunity. The necessity for this response is well illustrated by the example of IFN-gamma and IL-12 gene knockout mice that rapidly succumb to the effects of acute infection. The parasite itself is skilled at sparking complex interactions in the innate immune system that lead to protective immunity. Neutrophils are one of the first cell types to arrive at the site of infection, and the cells release several proinflammatory cytokines and chemokines in response to Toxoplasma. Dendritic cells are an important source of IL-12 during infection with T. gondii and other microbial pathogens, and they are also specialized for high-level antigen presentation to T lymphocytes. Tachyzoites express at least two types of molecules that trigger innate immune cell cytokine production. One of these involves Toll-like receptor/MyD88 pathways common to many microbial pathogens. The second pathway is less conventional and involves molecular mimicry between a parasite cyclophilin and host CC chemokine receptor 5-binding ligands. Neutrophils, dendritic cells and Toxoplasma work together to elicit the immune response required for host survival. Cytokine and chemokine cross-talk between parasite-triggered neutrophils and dendritic cells results in recruitment, maturation and activation of the latter. Neutrophil-empowered dendritic cells possess properties expected of highly potent antigen presenting cells that drive T helper 1 generation. (C) 2003 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.