Human immunopathogenesis of severe acute respiratory syndrome (SARS).
Human immunopathogenesis of severe acute respiratory syndrome (SARS).
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DOI：
10.1016/j.virusres.2007.02.014
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发表时间：
2008-04
期刊：
影响因子：
5
通讯作者：
Kelvin DJ
中科院分区：
文献类型：
--
作者：
Cameron MJ;Bermejo-Martin JF;Danesh A;Muller MP;Kelvin DJ
进行性免疫相关损伤是严重急性呼吸综合征（SARS）的一个标志。SARS冠状病毒（SARSCoV）感染宿主的病毒逃避天然免疫、高细胞因子血症和全身免疫病理学被认为是导致SARS患者严重病理和发病的可能机制。然而，SARS冠状病毒如何影响宿主免疫系统导致严重SARS的分子和细胞基础尚未阐明。SARS临床过程的变化可能是宿主对感染因子反应的复杂程序的结果。因此，系统分析SARS冠状病毒的先天性和适应性免疫反应，建立尽可能完整的免疫学模型，在疾病期间的宿主免疫和炎症反应是必要的。在这里，我们回顾了SARS免疫发病机制研究的最新进展，并提出了一个总结我们的研究结果有关SARS患者的宿主反应。我们认为，失调的I型和II型干扰素（IFN）的反应在SARS期间可能会导致失败的开关从超先天免疫保护性适应性免疫反应在人类宿主。
Progressive immune-associated injury is a hallmark of severe acute respiratory syndrome (SARS). Viral evasion of innate immunity, hypercytokinemia and systemic immunopathology in the SARS coronavirus (SARS CoV) infected host have been suggested as possible mechanisms for the cause of severe pathology and morbidity in SARS patients. The molecular and cellular basis for how SARS CoV impacts the host immune system resulting in severe SARS, however, has not been elucidated. The variable clinical course of SARS may be the result of complex programs of host responses against the infectious agent. Therefore, the systematic analysis of innate and adaptive immune responses to SARS CoV is imperative in building as complete an immunological model as possible of host immunity and inflammatory responses during illness. Here we review recent advances in SARS immunopathogenesis research and present a summary of our findings regarding host responses in SARS patients. We contend that dysregulated type I and II interferon (IFN) responses during SARS may culminate in a failure of the switch from hyper-innate immunity to protective adaptive immune responses in the human host.
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影响因子：
64.8
作者：
Li W;Moore MJ;Vasilieva N;Sui J;Wong SK;Berne MA;Somasundaran M;Sullivan JL;Luzuriaga K;Greenough TC;Choe H;Farzan M
通讯作者：
Farzan M
DOI：
10.1007/s10096-006-0127-x
发表时间：
2006-04
期刊：
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
影响因子：
--
作者：
Muller MP;Richardson SE;McGeer A;Dresser L;Raboud J;Mazzulli T;Loeb M;Louie M;Canadian SARS Research Network
通讯作者：
Canadian SARS Research Network
影响因子：
120.7
作者：
Fowler, RA;Lapinsky, SE;Stewart, TE
通讯作者：
Stewart, TE
影响因子：
82.9
作者：
Kuba K;Imai Y;Rao S;Gao H;Guo F;Guan B;Huan Y;Yang P;Zhang Y;Deng W;Bao L;Zhang B;Liu G;Wang Z;Chappell M;Liu Y;Zheng D;Leibbrandt A;Wada T;Slutsky AS;Liu D;Qin C;Jiang C;Penninger JM
通讯作者：
Penninger JM
DOI：
10.1016/s0140-6736(03)13413-7
发表时间：
2003-05-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Nicholls JM;Poon LL;Lee KC;Ng WF;Lai ST;Leung CY;Chu CM;Hui PK;Mak KL;Lim W;Yan KW;Chan KH;Tsang NC;Guan Y;Yuen KY;Peiris JS
通讯作者：
Peiris JS