The lymphocyte transformation test for the diagnosis of drug allergy: Sensitivity and specificity
The lymphocyte transformation test for the diagnosis of drug allergy: Sensitivity and specificity
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DOI：
10.1111/j.1365-2222.1997.tb00690.x
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发表时间：
1997-02-01
影响因子：
6.1
通讯作者：
Pichler, WJ
中科院分区：
文献类型：
--
作者：
Nyfeler, B;Pichler, WJ
Background The diagnosis of a drug allergy is mainly based upon a very detailed history and the clinical findings. In addition, several in vitro or in vivo tests can be performed to demonstrate a sensitization to a certain drug. One of the in vitro tests is the lymphocyte transformation test (LTT), which can reveal a sensitization of T-cells by an enhanced proliferative response of peripheral blood mononuclear cells to a certain drug.Objective To evaluate the sensitivity and specificity of the LTT, 923 case histories of patients with suspected drug allergy in whom a LTT was performed were retrospectively analysed.Methods Based on the history and provocation tests, the probability (P) of a drug allergy was estimated to be >0.9, 0.5-0.9, 0.1-0.5 or 0.9) had a positive LTT, which indicates a sensitivity of 78%. If allergies to betalactam-antibiotics were analysed separately, the sensitivity was 74.4%. Fifteen of 102 patients where a classical drug allergy could be excluded (P
