Interaction Potential between Biological Sensing Nanoparticles Determined by Combining Small-Angle X-ray Scattering and Model-Potential-Free Liquid Theory
Interaction Potential between Biological Sensing Nanoparticles Determined by Combining Small-Angle X-ray Scattering and Model-Potential-Free Liquid Theory
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DOI：
10.1021/acs.jpcc.6b06487
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发表时间：
2016-10
影响因子：
3.7
通讯作者：
T. Morita;N. Uehara;Kenji Kuwahata;H. Imamura;T. Shimada;K. Ookubo;Maki Fujita;T. Sumi
中科院分区：
文献类型：
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作者：
T. Morita;N. Uehara;Kenji Kuwahata;H. Imamura;T. Shimada;K. Ookubo;Maki Fujita;T. Sumi
利用纳米颗粒的生物传感技术扩展到不同的领域。纳米传感是通过纳米颗粒之间的相互作用力主导的纳米颗粒的组装/拆卸来控制的。尽管相互作用势面提供了关于传感机制的决定性信息，但由于共轭软物质的极其复杂的相互作用，评估定量剖面是不可能的。在这项研究中，结合小角散射和液态理论，设计了一种无模型势的相互作用势面的确定方法。胶体纳米粒子的无模型无势液体理论因其纳米尺度的大小而固有地具有很强的范德华引力。本方法提取纳米颗粒之间的相互作用势，即使在由于共轭软物质而具有复杂相互作用的系统中也是如此。通过将这种测定方法应用于谷胱甘肽触发的生物传感反应，相互作用有效地...
Biological sensing technology utilizing nanoparticles extends through a diverse range of fields. The nanosensing is controlled using the assembly/disassembly of nanoparticles dominated by interaction forces between them. Although the interaction potential surface gives decisive information on the sensing mechanism, evaluating the quantitative profile has been impossible due to extremely complicated interactions of conjugated soft matter. In this study, a model-potential-free determination of the interaction potential surfaces was devised by combining small-angle scattering and liquid-state theory. The model-potential-free liquid theory was developed for colloidal nanoparticles inherently with strong van der Waals attraction forces by their nanoscopic size. The present method extracts interaction potential between nanoparticles even in systems with complicated interactions due to conjugated soft matter. By applying this determination method to a glutathione-triggered biosensing reaction, interaction potent...