Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women
Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women
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DOI：
10.1093/aje/kwh346
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发表时间：
2004-12-15
影响因子：
5
通讯作者：
Zheng, TZ
中科院分区：
文献类型：
--
作者：
Zhang, YW;Wise, JP;Zheng, TZ
最近的流行病学研究表明，细胞色素P-450 1A 1基因（CYP 1A 1）的遗传多态性可能会影响环境暴露多氯联苯（PCBs）和乳腺癌风险之间的关系。作者报告了一项病例对照研究的结果，该研究评估了CYP 1A 1和血清PCB水平之间的基因-环境相互作用对康涅狄格州白人女性乳腺癌风险的潜在影响。本研究收集了374例经组织学证实的乳腺癌患者和406例非乳腺癌对照者的血清PCB水平和CYP 1A 1基因型信息（1999-2002年）。与纯合野生型CYP 1A 1 m2基因型女性相比，CYP 1A 1 m2变异基因型女性患乳腺癌的风险显著增加（比值比（OR）= 2.1，95%置信区间（CI）：1.1，3.9），尤其是绝经后女性（OR = 2.4，95% CI：1.1，5.0）。血清PCB水平较高（611- 2，600 ng/g）的所有女性（OR = 3.6，95% CI：1.5，8.2）和绝经后女性（OR = 4.3，95% CI：1.6，12.0）与CYP 1A 1 m2变异基因型相关的风险最高。CYP 1A 1 m1和m4基因型与乳腺癌风险无关，也与PCB暴露无关。总之，CYP 1A 1 m2基因多态性与女性乳腺癌风险增加有关，并可能改变PCB暴露与乳腺癌风险之间的关系。
Recent epidemiologic studies have suggested that genetic polymorphisms in the cytochrome P-450 1A1 gene (CYP1A1) may affect the relation between environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk. The authors report results from a case-control study evaluating the potential effect of gene-environment interaction between CYP1A1 and serum PCB levels on breast cancer risk among Caucasian women in Connecticut. The study included 374 case women with histologically confirmed breast cancer and 406 noncancerous controls with information on both serum PCB level and CYP1A1 genotype (1999-2002). Compared with women who had the homozygous wild-type CYP1A1 m2 genotype, significantly increased risks of breast cancer were found for women with the CYP1A1 m2 variant genotype (odds ratio (OR) = 2.1, 95% confidence interval (CI): 1.1, 3.9), especially postmenopausal women (OR = 2.4, 95% CI: 1.1, 5.0). Risks associated with the CYP1A1 m2 variant genotype were highest for all women (OR = 3.6, 95% CI: 1.5, 8.2) and postmenopausal women (OR = 4.3, 95% CI: 1.6, 12.0) with higher serum PCB levels (611-2,600 ng/g). The CYP1A1 m1 and m4 genotypes were not associated with breast cancer risk independently or in combination with PCB exposure. In summary, the CYP1A1 m2 genetic polymorphism was associated with increased risk of female breast cancer and may modify the relation between PCB exposure and breast cancer risk.