Poly's plea: membership to the club of APCs
Poly's plea: membership to the club of APCs
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DOI：
10.1016/s1471-4906(03)00235-7
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发表时间：
2003-09-01
影响因子：
16.8
通讯作者：
Saha, B
中科院分区：
文献类型：
--
作者：
Ashtekar, AR;Saha, B
多形核中性粒细胞 (PMN) 约占外周血白细胞的三分之二，在未感染、未受伤的“健康”组织中不存在。 PMN 被认为是终末分化且转录失活的，是第一个迁移到感染部位进行吞噬作用并释放细胞毒性化合物的细胞。最近的数据显示，PMN 主动获取抗原，转录和表达 MHC I 类和 II 类分子、共刺激分子以及几种诱导 T 细胞迁移和分化的功能多样的细胞因子和趋化因子的基因。因此，PMN 不仅充当先天免疫系统的吞噬清道夫和非特异性效应器，而且还通过在感染性和自身免疫性疾病中处理并向 T 细胞呈递抗原，作为 T 依赖性免疫反应的重要诱导剂。
Polymorphonuclear neutrophils (PMNs), comprising about two-thirds of peripheral blood leukocytes, are absent from uninfected, uninjured, 'healthy' tissues. PMNs, proposed to be terminally differentiated and transcriptionally inactive, are the first cells to migrate to the site of infection to perform phagocytosis and to release cytotoxic compounds. Recent data reveal that PMNs actively acquire antigens, transcribe and express the genes for MHC class I and class II molecules, costimulatory molecules and several functionally diverse cytokines and chemokines that induce T-cell migration and differentiation. Thus, PMNs act not only as phagocytic scavengers and non-specific effectors of the innate immune system but also as significant inducers of T-dependent immune responses by processing and presenting antigens to T-cells in infectious and autoimmune diseases.