Ratiometric Analysis of In Vivo Optical Coherence Tomography Retinal Layer Thicknesses for Detection of Changes in Alzheimer's Disease.
Ratiometric Analysis of In Vivo Optical Coherence Tomography Retinal Layer Thicknesses for Detection of Changes in Alzheimer's Disease.
复制标题
体内光学相干断层扫描视网膜层厚度的比例分析用于检测阿尔茨海默病的变化。
DOI：
10.1002/tbio.202300003
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发表时间：
2023
影响因子：
--
通讯作者：
Boppart,StephenA
中科院分区：
文献类型：
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作者：
Sharma,ShonitN;Marsh,JordanW;Tsipursky,MichaelS;Boppart,StephenA
我们分析了阿尔茨海默病(AD)患者的眼部视网膜光学相干断层扫描(OCT)图像，以确定视网膜层厚度和比率的变化，这些变化可能作为该疾病基于图像的生物标志物。对48例患者诊断前和诊断后各1个三维体积进行分割，以识别视网膜层和视网膜总厚度。在诊断前和诊断后的视网膜OCT图像之间，所有48名患者的10个视网膜层中有6个(60%)有显著的厚度变化。通过与年龄匹配的健康受试者的比较，这些显著变化归因于仅AD(NFL和PR2层)、仅AGE(GCL、IPL和RPE层)或AD和AGE两者(OPL层)。分析视网膜层厚度比率，90个比率中有53个比率(58.89%)有显著变化。这四个独立的不显著层被评估为既不受AD也不受年龄的影响(INL层)，或者既不受AD也不受年龄的影响(ELM、PR1和BM层)。AD患者视网膜层的图像分割、测量和比率分析可能产生一种基于OCT图像的非侵入性视网膜生物标志物，可用于检测与该疾病相关的视网膜变化。
We analyzed ophthalmic retinal optical coherence tomography (OCT) images from patients with Alzheimer's disease (AD) to identify retinal layer thickness and ratio changes that may serve as image‐based biomarkers for the disease. One three‐dimensional volume before and one after diagnosis for each of 48 patients were segmented to identify retinal layer and total retinal thicknesses. Between before‐ and after‐diagnosis retinal OCT images, there were significant thickness changes in six of 10 (60%) retinal layers across all 48 patients. Through a comparison with age‐matched healthy subjects, the significant changes were attributed to AD only (NFL and PR2 layers), age only (GCL, IPL, and RPE layers), or both AD and age (OPL layer). Analyzing ratios of retinal layer thicknesses, 53 of 90 (58.89%) ratios had significant changes. The four independently nonsignificant layers were assessed to be affected by neither AD nor age (INL layer) or both AD and age (ELM, PR1, and BM layers). The demonstrated image segmentation, measurement, and ratiometric analysis of retinal layers in AD patients may yield a noninvasive OCT image‐based retinal biomarker that can be used to detect retinal changes associated with this disease.