Cellular adhesion molecules as targets for bacterial infection
Cellular adhesion molecules as targets for bacterial infection
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DOI：
10.1016/j.ejcb.2005.08.002
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发表时间：
2006-04-01
影响因子：
6.6
通讯作者：
Schmitter, T
中科院分区：
文献类型：
--
作者：
Hauck, CR;Agerer, F;Schmitter, T
大量的细菌病原体以细胞黏附分子为靶标，与宿主细胞和组织建立密切联系。整合素、钙粘附素和免疫球蛋白相关细胞黏附分子(IgCAM)家族的成员通常被特定的细菌表面蛋白识别。结合可以在细胞骨架重排后触发细菌内化，细胞骨架重排是在受体聚集时启动的。此外，从被占据的受体发出的信号可以导致细胞反应，例如影响感染细胞表型的基因表达事件。本文将通过讨论整合素与金黄色葡萄球菌的结合以及致病性奈瑟氏菌对IgCAM的开发来阐述细菌与细胞黏附分子结合的最新进展。(C)2005年爱思唯尔股份有限公司。版权所有。
A large number of bacterial pathogens targets cell adhesion molecules to establish an intimate contact with host cells and tissues. Members of the integrin, cadherin and immunoglobulin-related cell adhesion molecule (IgCAM) families are frequently recognized by specific bacterial surface proteins. Binding can trigger bacterial internalization following cytoskeletal rearrangements that are initiated upon receptor clustering. Moreover, signals emanating from the occupied receptors can result in cellular responses such as gene expression events that influence the phenotype of the infected cell. This review will address recent advances in our understanding of bacterial engagement of cellular adhesion molecules by discussing the binding of integrins by Staphylococcus aureus as well as the exploitation of IgCAMs by pathogenic Neisseria species. (c) 2005 Elsevier GmbH. All rights reserved.