Multiple co-existing antibodies in autoimmune encephalitis: A case and review of the literature
Multiple co-existing antibodies in autoimmune encephalitis: A case and review of the literature
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DOI：
10.1016/j.jneuroim.2019.577084
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发表时间：
2019-12-15
影响因子：
3.3
通讯作者：
Piquet, Amanda L.
中科院分区：
文献类型：
--
作者：
Kammeyer, Ryan;Piquet, Amanda L.
一名66岁男性，有长期吸烟史，表现为两个月的进行性记忆缺陷、共济失调、复视和眼阵挛。他的脑部磁共振成像（MRI）显示边缘系统和脑干脑炎，抗Ma 1/Ma 2、抗N-甲基-D-天冬氨酸受体（抗NMDA-R）和抗谷氨酸脱羧酶65（抗GAD 65）抗体检测呈阳性。他的脑炎改善静脉类固醇，血浆置换，利妥昔单抗开始。他的PET/CT疑似肺部恶性肿瘤，但他的呼吸状态进行性恶化，无法进行全面调查。多种自身抗体可能会产生在恶性肿瘤和重叠的临床表现可能会出现多种自身抗体。
A 66-year-old man with a history of chronic tobacco use presented with two months of progressive memory deficits, ataxia, diplopia, and opsoclonus. His brain magnetic resonance imaging (MRI) showed limbic and brainstem encephalitis, and antibody testing was positive for anti-Ma1/Ma2, anti-N-methyl-D-aspartate receptor (anti-NMDA-R) and anti-glutamic acid decarboxylase 65 (anti-GAD65) antibodies. His encephalitis improved with intravenous steroids, plasmapheresis, and rituximab initiation. His PET/CT was suspicious for lung malignancy, but a progressive deterioration of his respiratory status prevented full investigation. Multiple auto-antibodies may be produced in response to a malignancy and overlapping of clinical presentations may occur with multiple auto-antibodies.