[Influence of combined therapy of guben yiliu III, moxibustion and chemotherapy on immune function and blood coagulation mechanism in patients with mid-late stage malignant tumor].
[Influence of combined therapy of guben yiliu III, moxibustion and chemotherapy on immune function and blood coagulation mechanism in patients with mid-late stage malignant tumor].
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发表时间：
2002-02
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通讯作者：
Ju Liu;R. Yu;W. Tang
中科院分区：
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作者：
Ju Liu;R. Yu;W. Tang
目的观察艾灸和中药复方固本抑瘤Ⅲ号对化疗的辅助作用。方法将81例中晚期恶性肿瘤患者随机分为3组：A组16例，化疗加安慰剂治疗; B组35例，化疗加银杏叶灵治疗; C组30例，化疗加银杏叶灵治疗加艾灸治疗。观察两组近期疗效、血象、细胞免疫功能及凝血功能的变化。结果化疗后，A、B组淋巴细胞计数明显降低（P0.05），B组T3淋巴细胞亚群明显升高，A组T淋巴细胞亚群平均水平降低，B、C组T淋巴细胞亚群平均水平升高，C组血浆纤维蛋白原浓度呈双向调节（P < 0.05）。结论莫西沙星可预防化疗所致淋巴细胞计数下降。固脾灵与艾灸联合应用可预防化疗引起的T淋巴细胞亚群下降，艾灸可双向调节患者部分凝血机制的异常。
OBJECTIVE To observe the supplementary effect of moxibustion and Guben Yiliu III (GBYL), a Chinese herbal compound preparation, in combination with chemotherapy. METHODS Eighty-one patients of mid-late stage malignant tumor were randomly divided into 3 groups: 16 in Group A treated with chemotherapy and placebo; 35 in Group B treated with chemotherapy and GBYL and 30 in Group C treated with chemotherapy and GBYL plus moxibustion. The short-term effect of treatment, changes of blood picture, cell mediated immune function and blood coagulation in patients were observed. RESULTS After chemotherapy, the lymphocyte count was significantly lowered in Group A and B (P 0.05); lymphocyte subset T3 raised significantly in Group B; the average level of T-lymphocyte subsets was reduced in Group A while it increased in the other two groups; and a bi-directional regulation on plasma fibrinogen concentration was shown in Group C (P < 0.05). CONCLUSION Moxibustion prevented dropping of lymphocyte count caused by chemotherapy. Combination of GBYL and moxibustion could prevent the lowering of T-lymphocyte subsets caused by chemotherapy, and moxibustion could regulate bi-directionally the patients' abnormality in part of blood coagulation mechanism.