Diesel exhaust as a model xenobiotic in allergic inflammation
Diesel exhaust as a model xenobiotic in allergic inflammation
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DOI：
10.1016/s0162-3109(00)00234-4
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发表时间：
2000-07-25
期刊：
影响因子：
--
通讯作者：
Diaz-Sanchez, D
中科院分区：
文献类型：
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作者：
Saxon, A;Diaz-Sanchez, D
我们利用活体人类鼻腔激发试验，研究了柴油机尾气微粒对人体过敏反应的影响。柴油颗粒和菲(其组成的多芳烃之一)被证明可以增加总过敏抗体(IgE)的产生，在有过敏原存在的情况下增强过敏原特异性的IEE，并诱导对新抗原的敏化。(C)2000 Elsevier Science B.V.保留所有权利。
We investigated the effects of diesel exhaust particulates on the human allergic response using in vivo human nasal challenges. Diesel particles and phenanthrene, one of their constituent polyaromatic hydrocarbons, were shown to enhance total allergic antibody (IgE) production, enhance allergen-specific IEE in the presence of allergen, and induce sensitization to a neoantigen. (C) 2000 Elsevier Science B.V. All rights reserved.