Malnutrition and humoral immunity: short-term acute nutritional deprivation.
Malnutrition and humoral immunity: short-term acute nutritional deprivation.
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发表时间：
1985-10
期刊：
影响因子：
3.8
通讯作者：
C. Nohr;J. Tchervenkov;J. Meakins;N. Christou
中科院分区：
文献类型：
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作者：
C. Nohr;J. Tchervenkov;J. Meakins;N. Christou
研究了短期急性营养剥夺和重新喂养对大鼠免疫功能的影响。先前对匙孔血蓝蛋白敏感的动物被饥饿72小时并进食7天。回想一下，使用匙孔血蓝蛋白皮肤测试和破伤风类毒素（TT）免疫来评估迟发型超敏反应（DTH）和体液免疫反应。在重新喂食开始后，DTH 的抑郁程度达到了顶峰。饥饿期间早期抗 TT 反应受到抑制。经过一段时间的重新喂食足以恢复体重后，DTH 和抗 TT 反应都没有恢复正常。数据表明，短期急性营养缺乏可能导致接受手术的患者出现获得性免疫缺陷。
The effects of short-term acute nutritional deprivation and refeeding on immune function was investigated in rats. Animals previously sensitized to keyhole-limpet hemocyanin were starved for 72 hours and refed for 7 days. Recall skin testing with keyhole-limpet hemocyanin and immunization with tetanus toxoid (TT) were used to assess delayed-type hypersensitivity (DTH) and humoral immune responses. DTH was maximally depressed late, after refeeding had begun. Anti-TT responses were depressed early during starvation. Neither DTH nor anti-TT responses had returned to normal after a period of refeeding sufficient to restore weight. The data indicate that short-term acute nutritional deprivation may contribute to acquired immunodeficiency in patients undergoing surgery.