Distinct pattern of human Vdelta1 gammadelta T cells recognizing MICA.
Distinct pattern of human Vdelta1 gammadelta T cells recognizing MICA.
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发表时间：
2005-08
影响因子：
24.1
通讯作者：
Jianqiang Li;L. Cui;Wei He
中科院分区：
文献类型：
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作者：
Jianqiang Li;L. Cui;Wei He
γ δ T细胞代表一种独特的识别模式，即有限识别，其区别于α T细胞的特异性识别和巨噬细胞的模式识别。Vdelta1 γ δ T细胞是人γ δ T细胞的主要亚群，其主要存在于包括肠上皮的粘膜组织中。目前，已经鉴定了人Vdelta1TCR可以识别的几种抗原。其中，MHC I类链相关分子A（云母）的研究最为深入。除了Vdelta1TCR，云母也是NKG2D的配体，NKG2D是一种C型凝集素样活化免疫受体。在人体中，只有Vdelta1细胞可以同时表达两种类型的云母受体，而NK细胞、γ δ T细胞和γ δ T细胞的其他亚群同样表达NKG2D。尽管确切的机制仍然是谜，但这种识别云母的Vdelta1细胞的独特模式预测了Vdelta1细胞在免疫防御中的独特生物学意义。近年来，这方面的研究取得了一定的进展。本文在总结前人研究成果的基础上，提出了一些新的观点。
Gammadelta T cells represent one unique recognition pattern, the limited recognition, which distinguishes from the specific recognition for alphabeta T cells and pattern recognition for macrophages. Vdelta1 gammadelta T cell is the major subset of human gammadelta T cells, which predominates in mucosal tissue including the intestinal epithelia. Presently, a few antigens that human Vdelta1TCR can recognize have been identified. Among them, MHC class I chain-related molecules A (MICA) have been studied most intensively. Besides Vdelta1TCR, MICA is also the ligand of NKG2D, a C-type lectin-like activating immunoreceptor. In human, only Vdelta1 cells can simultaneously express both types of receptors of MICA while NK cells, alphabetaT cells and other subsets of gammadelta T cells likewise express NKG2D. Although the precise mechanisms are still enigmatic, this distinct pattern of Vdelta1 cells recognizing MICA predicts unique biological significance of Vdelta1 cells in immune defense. Recent years, some progresses have been made in this issue. In this review we summarize the related reports and put forward some novel views based on our group's studies.