FIBROBLASTS AS EFFICIENT ANTIGEN-PRESENTING CELLS IN LYMPHOID ORGANS
FIBROBLASTS AS EFFICIENT ANTIGEN-PRESENTING CELLS IN LYMPHOID ORGANS
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DOI：
10.1126/science.7761853
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发表时间：
1995-06-02
期刊：
影响因子：
56.9
通讯作者：
ZINKERNAGEL, RM
中科院分区：
文献类型：
--
作者：
KUNDIG, TM;BACHMANN, MF;ZINKERNAGEL, RM
只有所谓的“专业”造血来源的抗原呈递细胞（APCs）被认为能够诱导T淋巴细胞反应。然而，在体内，转染病毒蛋白的成纤维细胞直接诱导抗病毒细胞毒性T淋巴细胞反应，而不涉及宿主apc。成纤维细胞仅在淋巴器官环境中诱导T细胞。因此，抗原定位影响自我-非自我区分和基于细胞的疫苗策略。
Only so-called ''professional'' antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.