Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
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DOI：
10.1038/ng.3195
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发表时间：
2015-03-01
期刊：
影响因子：
30.8
通讯作者：
Wirth, Thierrv
中科院分区：
文献类型：
--
作者：
Merker, Matthias;Blin, Camille;Wirth, Thierrv
北京谱系的结核分枝杆菌菌株在全球分布，并与欧亚大陆多药耐药（MDR）结核病的大规模传播有关。在这里，我们通过对来自99个国家的4，987个分离株的遗传分析和110个代表性分离株的全基因组测序，重建了该谱系的地理结构和进化历史。我们发现，这一血统最初起源于远东，从那里它辐射到世界各地的几个波。在过去的200年里，我们发现这种病原体的人口规模连续增加，几乎与工业革命，第一次世界大战和艾滋病毒流行一致。随着前苏联公共卫生系统的崩溃，这一谱系的两个MDR克隆开始在中亚和俄罗斯传播。在阳性选择下，在puppet基因中发现的与毒力相关的突变可能有利于该谱系最成功分支的扩展。
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.