Multisystem inflammatory syndrome in children (MIS-C) and the coronavirus pandemic: Current knowledge and implications for public health.
Multisystem inflammatory syndrome in children (MIS-C) and the coronavirus pandemic: Current knowledge and implications for public health.
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DOI：
10.1016/j.jiph.2021.01.008
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发表时间：
2021-04
影响因子：
6.7
通讯作者：
Amirian ES
中科院分区：
文献类型：
--
作者：
Rafferty MS;Burrows H;Joseph JP;Leveille J;Nihtianova S;Amirian ES
2019年冠状病毒病（COVID-19）大流行导致了广泛的死亡率和发病率。虽然儿童基本上免于严重的疾病，但一种新的儿童高炎症综合征已经出现，这种综合征被认为与严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）感染有关，并随后出现，可能导致严重后果。儿童多系统炎性疾病（MIS-C）最常见于年幼的学龄儿童，其特征为持续发热、全身性炎症过度和多系统器官功能障碍。虽然不常见且一般可治疗，但MIS-C存在潜在的改变生活的医学后遗症，由于缺乏有关其病因学，病理生理学和长期结局的信息而变得复杂。MIS-C的严重性可能需要提高认识和持续的COVID-19缓解工作，特别是在通过额外的研究澄清导致MIS-C易感性的潜在因素之前。随着学年的进展，知情的指导方针将是至关重要的。在这篇文章中，MIS-C的现有知识进行了审查，并从公共卫生的角度讨论了这种新的综合征的潜在影响。
The coronavirus disease 2019 (COVID-19) pandemic has caused widespread mortality and morbidity. Though children are largely spared from severe illness, a novel childhood hyperinflammatory syndrome presumed to be associated with and subsequent to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has emerged with potentially severe outcomes. Multisystem inflammatory disorder in children (MIS-C) most commonly affects young, school-aged children and is characterized by persistent fever, systemic hyperinflammation, and multisystem organ dysfunction. While uncommon and generally treatable, MIS-C presents potentially life-altering medical sequelae, complicated by a dearth of information regarding its etiology, pathophysiology, and long-term outcomes. The severity of MIS-C may warrant the need for increased awareness and continued COVID-19 mitigation efforts, particularly until potential factors conferring a predisposition to MIS-C can be clarified through additional research. Well-informed guidelines will be critical as the school year progresses. In this article, current knowledge on MIS-C is reviewed and the potential implications of this novel syndrome are discussed from a public health perspective.
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