A Novel Opal Closest-Packing Photonic Crystal for Naked-Eye Glucose Detection
A Novel Opal Closest-Packing Photonic Crystal for Naked-Eye Glucose Detection
复制标题
用于肉眼血糖检测的新型蛋白石最密堆积光子晶体
DOI：
10.1002/smll.201302788
复制
发表时间：
2014-04-01
期刊：
影响因子：
13.3
通讯作者：
Gao, Zhixian
中科院分区：
文献类型：
--
作者：
Hong, Xiaodi;Peng, Yuan;Gao, Zhixian
成功制备了一种用于葡萄糖检测的蛋白石密堆积光子晶体。这种PC是通过垂直对流自组装方法与一种新型的单分散微球聚合的共聚单体，即甲基丙烯酸甲酯（MMA），N-异丙基丙烯酰胺（NIPA），3-丙烯酰胺基苯基硼酸（AAPBA）。OCP PC具有高稳定性和有序结构，显示出所需的结构色。所提出的PC材料在检测葡萄糖分子时显示出红移和降低的反射强度。红移波长达到75 nm，这清楚地改变了结构颜色从灿烂的蓝色到翡翠绿色。这种视觉上可区分的颜色变化有助于检测3至20 mm的葡萄糖浓度，这证明了蛋白石PC材料用于裸眼检测的潜力。因此，新的PMMA-NIPA-AAPBA OCP PC是一种制备简单且灵敏的材料，其在糖尿病的诊断和糖尿病的实时监测中显示出有希望的用途。不同类型的合适识别基团有望被引入到3D OCP PC中，形成新的功能材料或化学传感器，这将广泛拓宽PC材料的应用。
A novel opal closest-packing (OCP) photonic crystal (PC) is successfully prepared for naked-eye glucose detection. This PC is fabricated via a vertical convective self-assembly method with a new type of monodisperse microsphere polymerized by co-monomers, namely, methyl methacrylate (MMA), N-isopropylacrylamide (NIPA), and 3-acrylamidophenylboronic acid (AAPBA). The OCP PC has high stability and periodically-ordered structure, showing the desired structural color. The proposed PC material displays a red shift and reduced reflection intensity when detecting glucose molecules. The red-shift wavelength reaches 75 nm, which clearly changes the structural color from brilliant blue to emerald green. This visually distinguishable color change facilitates the detection of the glucose concentrations from 3 to 20 mm, which demonstrates the potential of the opal PC material for naked-eye detection. Thus, the novel PMMA-NIPA-AAPBA OCP PC is a simply prepared and sensitive material, which shows promising use in the diagnosis of diabetes mellitus and in real-time monitoring of diabetes. Different types of appropriated recognition groups are expected to be introduced into the 3D OCP PC to form new functional materials or chemical sensors, which will extensively broaden the PC material application.