Sustained Drug Release Characteristics of Biodegradable Composite Poly(d,l)Lactic Acidpoly(I)Lactic Acid Microcapsules Containing Ciprofloxacin
Sustained Drug Release Characteristics of Biodegradable Composite Poly(d,l)Lactic Acidpoly(I)Lactic Acid Microcapsules Containing Ciprofloxacin
复制标题
含环丙沙星的可生物降解复合聚(d,l)乳酸聚(I)乳酸微胶囊的缓释特性
DOI：
10.3109/10731190009119784
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
T. Chang
中科院分区：
文献类型：
--
作者：
W. P. Yu;J. P. Wong;T. Chang
采用相分离法制备了环丙沙星聚乳酸微囊。将聚（d，l）乳酸和聚（l）乳酸两种类型的聚乳酸组合作为膜材料，以防止相分离过程中经常发生的聚集现象。微囊的聚合物组成影响环丙沙星的释放速率。药物的最佳释放速率可以通过改变微胶囊组合物来获得。聚（d，l）乳酸在减缓药物释放速率方面比聚（l）乳酸优越上级。然而，聚（I）乳酸在微胶囊的制备中是必要的以防止聚集。
Ciprofloxacin polylactic microcapsules were prepared by the phase separation process. Two types of polylactic acid, poly(d,l)lactic acid and poly(l)lactic acid were combined as membrane materials to prevent the aggregation which happened frequently in the phase separation process. The polymer compositions of the microcapsules can influence the release rate of Ciprofloxacin. The optimal release rate of the drug can be obtained by modifying microcapsule compositions. Poly(d,l)lactic acid is superior in slowing the rate of drug release than poly(l)lactic acid. However, poly(l)lactic acid is necessary in the preparation of the microcapsules to prevent aggregation.