Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases
Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases
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DOI：
10.1128/aac.03053-15
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发表时间：
2016-04-01
影响因子：
4.9
通讯作者：
Kreiswirth, Barry N.
中科院分区：
文献类型：
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作者：
Du, Hong;Chen, Liang;Kreiswirth, Barry N.
在这里，我们报告了两个阴沟肠杆菌序列型231分离株，共产生KPC-3和NDM-1，已造成致命的感染，在三级医院在中国。含有bla（NDM-1）的质粒携带印加/C-2和IncR复制子，显示出嵌合质粒结构，并且bla（NDM-1）位于新的I类整合子样元件上。bla（KPC-3）位于Tn 3-Delta bla（TEM-1）-bla（KPC-3）-Delta Tn 1722元件上，侧翼为两个9-bp直接重复序列，并位于IncX 6质粒上。
Here, we report two Enterobacter cloacae sequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. The bla(NDM-1)-harboring plasmids carry IncA/C-2 and IncR replicons, showing a mosaic plasmid structure, and the bla(NDM-1) is harbored on a novel class I integron-like element. bla(KPC-3) is located on a Tn3-Delta bla(TEM-1)-bla(KPC-3)-Delta Tn1722 element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.