Roles of neuropilins in neuronal development, angiogenesis, and cancers
Roles of neuropilins in neuronal development, angiogenesis, and cancers
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DOI：
10.1007/s00268-004-7818-1
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发表时间：
2005-03-01
影响因子：
2.6
通讯作者：
Yao, QH
中科院分区：
文献类型：
--
作者：
Chen, CY;Li, M;Yao, QH
Neuropilin-1 (NRP1) 和 Neuropilin-2 (NRP2) 是跨膜糖蛋白，已被定性为用于神经元引导的信号蛋白和用于血管生成的血管内皮生长因子 (VEGF) 的受体。 NRP 的生物学特性与其独特的结构域结构有关。然而，NRP、VEGF 和 VEGF 受体之间的分子相互作用仍不清楚。尽管多种类型的癌细胞可以表达 NRP，但 NRP 在肿瘤发病机制中的作用很大程度上未知。因此，未来的研究应包括确定 NRP 对神经元、内皮细胞和癌细胞的增殖、凋亡和迁移的影响和机制。蛋白质-蛋白质相互作用、信号转导途径和 NRP 介导的基因表达的研究对于了解 NRP 的功能尤为重要，这可能在神经系统疾病、心血管疾病和某些癌症的治疗中具有重要的临床应用。
Neuropilin-1 (NRP1) and neuropilin-2 (NRP2) are transmembrane glycoproteins that have been characterized as receptors for both semaphorins for neuronal guidance and vascular endothelial growth factor (VEGF) for angiogenesis. Biologic properties of NRPs have been linked to their unique domain structures. However, molecular interaction among NRPs, VEGF, and VEGF receptors is still not clear. Although several types of cancer cells can express NRPs, the role of NRPs in tumor pathogenesis is largely unknown. Thus, future investigations should include determining the effects and mechanisms of NRPs on proliferation, apoptosis, and migration of neuronal, endothelial, and cancer cells. Study of protein-protein interaction, signal transduction pathways, and NRP-mediated gene expression is particularly important to understand NRPs functions, which may have significant clinical applications in the treatment of neurological disorders, cardiovascular diseases, and certain cancers.