A biophysical model of short-term plasticity at the calyx of Held
A biophysical model of short-term plasticity at the calyx of Held
复制标题
Held 花萼短期可塑性的生物物理模型
DOI：
10.1016/j.neucom.2006.10.074
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发表时间：
2007
期刊：
影响因子：
6
通讯作者：
B. Graham
中科院分区：
文献类型：
--
作者：
Matthias H Hennig;M. Postlethwaite;I. Forsythe;B. Graham
赫尔德花萼是听觉系统中一个巨大的谷氨酸能突触，表现出多种形式的短期促进和抑制。本研究提出了该突触短期可塑性的详细模型。该模型的主要组成部分是突触前囊泡动力学，包括被动和活性依赖性循环，钙依赖性胞吐和突触后AMPA受体动力学。模型的行为与实验数据进行了比较，再现了不同频率重复刺激下突触抑制的时间过程和幅度。模型的不同操作的比较表明，准确的拟合需要包含快速活性依赖的囊泡循环和每个活性区域有限数量的囊泡对接点。
The calyx of Held is a giant glutamatergic synapse in the auditory system and displays multiple forms of short-term facilitation and depression. This study presents a detailed model of short-term plasticity at this synapse. The main components of the model are the presynaptic vesicle dynamics, which include passive and activity-dependent recycling, calcium-dependent exocytosis and the postsynaptic AMPA receptor kinetics. The behaviour of the model is compared to experimental data and reproduces the time course and amplitude of synaptic depression during repetitive stimulation at different frequencies. A comparison of different manipulations of the model shows that accurate fits require the inclusion of fast activity-dependent vesicle recycling and a limited number of vesicle docking sites at each active zone.