Activation of macrophages for microbicidal and tumoricidal effector functions by soluble factors from EL-4, a continuous T cell line
Activation of macrophages for microbicidal and tumoricidal effector functions by soluble factors from EL-4, a continuous T cell line
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通过 EL-4（一种连续 T 细胞系）的可溶性因子激活巨噬细胞以实现杀微生物和杀肿瘤效应功能
作者：
C. Nacy;S. James;W. Benjamin;JOHiN J. Farrar;W. Hockmeyer;M. Meltzer;A. C.;Nacy;A. Fortier;M. G. Pappas
用来自EL-4细胞（连续T细胞系）的培养液处理的巨噬细胞被激活以杀死mKSA-TU-5纤维肉瘤细胞、热带利什曼原虫的无鞭毛体和曼氏血吸虫的童虫。活性EL-4因子从Sephadex G-100洗脱在两个不同的区域：分子量45，000（活性诱导杀死不相关的细胞内和细胞外靶标）和分子量23，000（活性诱导杀死细胞外靶标）。这些结果证实了诱导巨噬细胞杀微生物和杀肿瘤活性的活化信号之间的异质性。诱导对细胞外肿瘤细胞和胚泡的杀细胞活性的因子与诱导细胞内无鞭毛体破坏的因子不同。
Macrophages treated with culture fluids from EL-4 cells, a continuous T cell line, were activated to kill mKSA-TU-5 fibrosarcoma cells, amastigotes of Leishmania tropica, and schistosomula of Schistosoma mansoni. Active EL-4 factors eluted from Sephadex G-100 in two distinct regions: molecular weight 45,000 (activities induced killing of unrelated intracellular and extracellular targets) and molecular weight 23,000 (activities induced killing of extracellular targets only). These results confirm heterogeneity among activation signals for the induction of macrophage microbicidal and tumoricidal activities. Factors that induced cytocidal activity against extracellular tumor cells and schistosomula were distinct from those that induced destruction of intracellular amastigotes.
硫代乙醇酸刺激和卡介苗激活的腹膜巨噬细胞的抗体依赖性细胞介导的细胞毒性（ADCC）的研究。
影响因子：
4.3
作者：
Koren,HS;Anderson,SJ;Adams,DO
通讯作者：
Adams,DO